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NLRC5 PANoptosome: Aquaman of the Dead Sea
Cell Research ( IF 28.1 ) Pub Date : 2024-08-07 , DOI: 10.1038/s41422-024-01011-5 Poonam S Jadhav 1 , Shreya Mahajan 1 , Si Ming Man 1
中文翻译：
NLRC5 PANoptosome：死海海王
更新日期：2024-08-07
Cell Research ( IF 28.1 ) Pub Date : 2024-08-07 , DOI: 10.1038/s41422-024-01011-5 Poonam S Jadhav 1 , Shreya Mahajan 1 , Si Ming Man 1
Affiliation
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Activation of innate immune sensors leads to the formation of inflammatory complexes called PANoptosomes that trigger inflammation and the lytic inflammatory cell death PANoptosis. A new study published in Cell now identified NLRC5 as a PANoptosome sensor that responds to NAD+ depletion triggered by heme plus PAMPs or heme plus TNF.
中文翻译：
NLRC5 PANoptosome：死海海王
先天免疫传感器的激活导致称为 PANoptosomes 的炎症复合物的形成，引发炎症和溶解性炎症细胞死亡 PANoptosis。发表在《Cell》上的一项新研究现已确定 NLRC5 是一种 PANoptosome 传感器，可响应血红素加 PAMP 或血红素加 TNF 触发的NAD +消耗。
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