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Triaptosis: an endosome-dependent cell death modality
Cell Research ( IF 28.1 ) Pub Date : 2024-12-06 , DOI: 10.1038/s41422-024-01053-9 Daolin Tang, Rui Kang, Guido Kroemer
中文翻译:
Triaptosis:一种内体依赖性细胞死亡模式
更新日期:2024-12-06
Cell Research ( IF 28.1 ) Pub Date : 2024-12-06 , DOI: 10.1038/s41422-024-01053-9 Daolin Tang, Rui Kang, Guido Kroemer
Recent research published in Science reveals that menadione, a precursor to vitamin K, induces a unique cell death pathway called triaptosis by oxidizing phosphatidylinositol 3-kinase PIK3C3/VPS34. This oxidation leads to endosomal dysfunction, highlighting how excessive oxidative stress can compromise cellular structures and activate specific cell death pathways.
中文翻译:
Triaptosis:一种内体依赖性细胞死亡模式
最近发表在《科学》杂志上的研究表明,甲萘醌是维生素 K 的前体,通过氧化磷脂酰肌醇 3-激酶 PIK3C3/VPS34 诱导一种称为 triaptosis 的独特细胞死亡途径。这种氧化导致内体功能障碍,突出了过度的氧化应激如何损害细胞结构并激活特定的细胞死亡途径。