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Yin and Yang of innate immune cell death
Cell Research ( IF 28.1 ) Pub Date : 2024-07-26 , DOI: 10.1038/s41422-024-01007-1 Yaqiu Wang 1 , Thirumala-Devi Kanneganti 1
中文翻译：
先天免疫细胞死亡的阴阳
更新日期：2024-07-26
Cell Research ( IF 28.1 ) Pub Date : 2024-07-26 , DOI: 10.1038/s41422-024-01007-1 Yaqiu Wang 1 , Thirumala-Devi Kanneganti 1
Affiliation
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Lytic innate immune cell death releases a variety of pathogen-associated and damage-associated molecular patterns, cytokines, metabolites and other molecules into the extracellular environment, where they can drive further physiological responses. In a recent study in Nature, Mehrotra et al. studied the secretome released during NLRP1B inflammasome-driven pyroptosis and identified that metabolites released by dying cells can promote wound healing.
中文翻译：
先天免疫细胞死亡的阴阳
裂解性先天免疫细胞死亡将多种病原体相关和损伤相关的分子模式、细胞因子、代谢物和其他分子释放到细胞外环境中，在那里它们可以驱动进一步的生理反应。在《自然》杂志最近的一项研究中，Mehrotra 等人。研究了 NLRP1B 炎症小体驱动的细胞焦亡过程中释放的分泌蛋白组，并发现死亡细胞释放的代谢物可以促进伤口愈合。
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