Dear Editor,

The proton-activated chloride (PAC) channel (also known as acid-sensitive outwardly rectifying anion channel, ASOR) plays critical roles in acid-induced cell death and endocytosis.^1,2 The structural investigations revealed that three protomers construct one PAC channel.^3,4,5 PAC’s three captured states (resting, activated, and desensitized) uncovered the gating and proton-sensing mechanism.^3,4,5 However, little is known about the regulatory factors of PAC.⁶

中文翻译：

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转移 RNA 抑制质子激活氯离子通道的分子见解

 亲爱的编辑，

质子激活氯离子 (PAC) 通道（也称为酸敏感的外向整流阴离子通道，ASOR）在酸诱导的细胞死亡和内吞作用中发挥着关键作用。 ^1,2 结构研究表明，三个原体构建了一个 PAC 通道。 ^3,4,5 PAC 的三种捕获状态（静止、激活和脱敏）揭示了门控和质子传感机制。 ^3,4,5 然而，人们对PAC的调控因素知之甚少。 ⁶