Molecular insights into the inhibition of proton-activated chloride channel by transfer RNA,Cell Research

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Molecular insights into the inhibition of proton-activated chloride channel by transfer RNA
Cell Research ( IF 28.1 ) Pub Date : 2024-06-28 , DOI: 10.1038/s41422-024-00993-6
Pengliang Chi ₁ , Xiang Wang ₁ , Jialu Li ₁ , Hui Yang ₂ , Kaiju Li _{1,

3} , Yuqi Zhang ₄ , Shiyi Lin ₄ , Leiye Yu _{5,

6} , Shiqi Liu ₂ , Lu Chen ₁ , Ruobing Ren _{5,

6} , Jianping Wu ₄ , Zhuo Huang ₂ , Jia Geng ₃ , Dong Deng _{1,

7}

Affiliation

Department of Obstetrics, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu, Sichuan, China.
State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing, China.
Department of Laboratory Medicine, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, China.
Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Westlake Laboratory of Life Sciences and Biomedicine, Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China.
Kobilka Institute of Innovative Drug Discovery, School of Life and Health Sciences, the Chinese University of Hong Kong, Shenzhen, Guangdong, China.
Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China.
Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, Sichuan, China.

Dear Editor,

The proton-activated chloride (PAC) channel (also known as acid-sensitive outwardly rectifying anion channel, ASOR) plays critical roles in acid-induced cell death and endocytosis.^1,2 The structural investigations revealed that three protomers construct one PAC channel.^3,4,5 PAC’s three captured states (resting, activated, and desensitized) uncovered the gating and proton-sensing mechanism.^3,4,5 However, little is known about the regulatory factors of PAC.⁶

中文翻译：

转移 RNA 对质子激活氯离子通道抑制的分子见解

尊敬的编辑：

质子激活氯离子（PAC）通道（也称为酸敏感外向整流阴离子通道，ASOR）在酸诱导的细胞死亡和内吞作用中起关键作用。^1,2 结构研究显示，三个原型构建了一个 PAC 通道。^3,4,5 PAC 的三种捕获状态（静息、激活和脱敏）揭示了门控和质子感应机制。^3,4,5 然而，人们对 PAC 的监管因素知之甚少。⁶

更新日期：2024-06-28

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