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Designing de novo D-protein binders
Cell Research ( IF 28.1 ) Pub Date : 2024-09-11 , DOI: 10.1038/s41422-024-01029-9 Haiyan Liu 1
中文翻译：
设计从头 D 蛋白结合剂
更新日期：2024-09-11
Cell Research ( IF 28.1 ) Pub Date : 2024-09-11 , DOI: 10.1038/s41422-024-01029-9 Haiyan Liu 1
Affiliation
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D-proteins hold considerable potential in biotechnological applications because of their generally anticipated higher bioorthogonality and stability over L-proteins. In a recent paper in Cell Research, Sun and colleagues demonstrated the successful design of de novo D-proteins that selectively bind to specific target regions of natural L-proteins or L-peptides.
中文翻译：
设计从头 D 蛋白结合剂
D 蛋白在生物技术应用中具有相当大的潜力，因为它们通常预期比 L 蛋白具有更高的生物正交性和稳定性。在最近发表在《细胞研究》上的 一篇论文中，Sun 及其同事展示了从头D 蛋白的成功设计，该蛋白选择性地结合天然 L 蛋白或 L 肽的特定靶区域。
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