The beneficial role of gasdermin activation and pyroptosis induction in antitumor immunity has been implicated by several studies; however, the question of how to specifically and efficiently activate cancer cell death while minimizing toxicity to host cells remains unsolved. In a recent paper published in Cell, Wu and Lieberman groups identified a GSDMD agonist that can induce low-level pyroptosis in cancer cells but not in host cells, offering potential applications in cancer vaccine development and therapy in combination with checkpoint blockade.

中文翻译：

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GSDMD 激动剂增强特异性抗肿瘤免疫

几项研究涉及 gasdermin 激活和焦亡诱导在抗肿瘤免疫中的有益作用;然而，如何特异性和有效地激活癌细胞死亡，同时最大限度地减少对宿主细胞的毒性的问题仍未解决。在最近发表在《细胞》上的一篇论文中，Wu 和 Lieberman 小组确定了一种 GSDMD 激动剂，该激动剂可以在癌细胞中诱导低水平焦亡，但不能在宿主细胞中诱导低水平焦亡，为癌症疫苗开发和治疗与检查点阻断相结合提供了潜在应用。