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PDK1 neddylation by Smurf1 drives Akt activation
Cell Research ( IF 28.1 ) Pub Date : 2024-08-29 , DOI: 10.1038/s41422-024-01020-4 Rajesh Kumar Manne 1 , Rajni Kant 1 , Hui-Kuan Lin 1
中文翻译：
Smurf1 的 PDK1 neddylation 驱动 Akt 激活
更新日期：2024-08-29
Cell Research ( IF 28.1 ) Pub Date : 2024-08-29 , DOI: 10.1038/s41422-024-01020-4 Rajesh Kumar Manne 1 , Rajni Kant 1 , Hui-Kuan Lin 1
Affiliation
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The PI3K/Akt pathway, one of the most frequently dysregulated signaling pathways in various cancers, plays a key role in tumorigenesis and resistance to chemotherapy. Recent discovery highlights an important regulatory step where Smurf1-mediated PDK1 neddylation through poly-Nedd8 chains is an early event for oncogenic Akt activation in KRAS-mutant colorectal cancer.
中文翻译：
Smurf1 的 PDK1 neddylation 驱动 Akt 激活
PI3K/Akt 通路是各种癌症中最常见失调的信号通路之一，在肿瘤发生和化疗耐药中发挥着关键作用。最近的发现强调了一个重要的调控步骤，即 Smurf1 通过聚 Nedd8 链介导的 PDK1 neddylation 是 KRAS 突变结直肠癌中致癌 Akt 激活的早期事件。
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