Painful memories boost protective immunity,Cell Research

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Painful memories boost protective immunity
Cell Research ( IF 28.1 ) Pub Date : 2024-07-18 , DOI: 10.1038/s41422-024-01002-6
Tri Giang Phan _{1,

2} , Elissa K Deenick _{1,

3}

Affiliation

How does pain, induced by inflammation, an innate immune response to tissue injury, impact humoral immunity, an adaptive immune response to infection? In a recent study in Cell, Wu et al. show that TRPV1⁺ nociceptive sensory neurons detect the inflammatory lipid mediator PGE₂ and release CGRP to activate the CALCRL/RAMP1 heterodimeric receptor, adenylate cyclase and cAMP signaling on B cells to boost the humoral immune response.

中文翻译：

痛苦的回忆增强保护性免疫力

由炎症引起的疼痛（一种对组织损伤的先天免疫反应）如何影响体液免疫（一种对感染的适应性免疫反应）？在最近的一项研究中细胞 Wu 等人表明，TRPV1 ⁺ 伤害性感觉神经元检测炎性脂质介质 PGE₂并释放 CGRP 以激活 B 细胞上的 CALCRL/RAMP1 异二聚体受体、腺苷酸环化酶和 cAMP 信号传导，以增强体液免疫反应。

更新日期：2024-07-18

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