An alteration in the lineage bias of aged hematopoietic stem cells (HSCs) has been implicated in the reduced immunity observed upon aging. Ross and colleagues now provide direct support for this hypothesis, demonstrating that a selective depletion of myeloid-biased HSCs in aged mice is accompanied by improvement in several parameters of immunity, uncovering a possible novel therapeutic avenue for counteracting age-related decline in immunity.

中文翻译：

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通过平衡干细胞作用恢复免疫力

衰老造血干细胞（HSC）谱系偏向的改变与衰老时观察到的免疫力下降有关。 Ross 及其同事现在为这一假设提供了直接支持，证明老年小鼠中骨髓偏向性 HSC 的选择性耗竭伴随着多个免疫参数的改善，从而揭示了一种可能的新治疗途径，用于对抗与年龄相关的免疫力下降。