Farnesyl pyrophosphate (FPP), an intermediate of cholesterol biosynthesis in the mevalonate pathway, prolongs the survival of migratory dendritic cells (mig-DCs) by remodelling mitochondrial structure and metabolism. Treating a mouse model of systemic lupus erythematosus with simvastatin (an inhibitor of this pathway) led to recovery from dysregulation in mig-DCs and ameliorated systemic autoimmune pathogenesis.

中文翻译：

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焦磷酸法呢酯调节狼疮自身免疫中的树突状细胞迁移


焦磷酸法呢酯 （FPP） 是甲羟戊酸途径中胆固醇生物合成的中间体，通过重塑线粒体结构和代谢来延长迁移树突状细胞 （mig-DC） 的存活时间。用辛伐他汀 （该通路的抑制剂） 治疗系统性红斑狼疮小鼠模型导致 mig-DC 失调恢复并改善系统性自身免疫发病机制。