A common feature of neurodegenerative diseases is that select neuronal types are particularly sensitive to disease pathology at early stages. Altered TrkB signalling in the neuronal type most affected by Huntington’s disease increased expression of the enzyme GSTO2, leading to dopaminergic dysfunction, impaired energy metabolism, progressive degeneration and hyperkinetic symptoms.

中文翻译：

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TrkB 信号传导通过代谢途径调节多巴胺回路和运动功能


神经退行性疾病的一个共同特征是，选定的神经元类型在早期对疾病病理特别敏感。受亨廷顿病影响最大的神经元类型的 TrkB 信号改变增加了 GSTO2 酶的表达，导致多巴胺能功能障碍、能量代谢受损、进行性变性和多动症状。