Itaconate is an immunomodulatory metabolite that influences the outcome of infections and inflammatory diseases. New evidence indicates that itaconate-induced inhibition of succinate dehydrogenase regulates type 1 interferon production via the release of mitochondrial RNA, linking TCA cycle modulation to antiviral interferon responses.

中文翻译：

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Itaconate 调节线粒体以对抗病毒 IFN-β


衣康酸盐是一种免疫调节代谢物，可影响感染和炎症性疾病的结果。新的证据表明，衣康酸盐诱导的琥珀酸脱氢酶抑制通过释放线粒体 RNA 调节 1 型干扰素的产生，将 TCA 循环调节与抗病毒干扰素反应联系起来。