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Affinity war: PSAT1 outcompetes the rest
Nature Metabolism ( IF 18.9 ) Pub Date : 2024-08-27 , DOI: 10.1038/s42255-024-01096-7
Richard Possemato 1, 2
Affiliation  

Resistance to glutamine restriction is mediated by increased serine synthesis. The high affinity of serine synthesis enzyme PSAT1 for glutamate drives sustained glutamine utilization. Combined pathway targeting limits tumour growth in mouse breast cancer models.

中文翻译:


亲和力战争:PSAT1 胜过其他人



对谷氨酰胺限制的抵抗力是通过增加丝氨酸合成来介导的。丝氨酸合成酶 PSAT1 对谷氨酸的高亲和力推动了谷氨酰胺的持续利用。联合途径靶向限制小鼠乳腺癌模型中的肿瘤生长。
更新日期:2024-08-27
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