Cold acclimation increases insulin sensitivity, and some level of muscle contraction appears to be needed for provoking this effect. Here 15 men and (postmenopausal) women with overweight or obesity, the majority of whom had impaired glucose tolerance, were intermittently exposed to cold to induce 1 h of shivering per day over 10 days. We determined the effect of cold acclimation with shivering on overnight fasted oral glucose tolerance (primary outcome) and on skeletal muscle glucose transporter 4 translocation (secondary outcome). We find that cold acclimation with shivering improves oral glucose tolerance, fasting glucose, triglycerides, non-esterified fatty acid concentrations and blood pressure. Cold acclimation with shivering may thus represent an alternative lifestyle approach for the prevention and treatment of obesity-related metabolic disorders. ClinicalTrials.gov registration: NCT04516018.

冷驯化会增加胰岛素敏感性，并且似乎需要一定程度的肌肉收缩才能激发这种效果。在这里，15 名超重或肥胖的男性和（绝经后）女性，其中大多数葡萄糖耐量受损，间歇性地暴露在寒冷中，在 10 天内每天诱导 1 小时的颤抖。我们确定了寒战冷驯化对过夜空腹口服葡萄糖耐量 （主要结局） 和骨骼肌葡萄糖转运蛋白 4 易位 （次要结局） 的影响。我们发现寒战的冷驯化可改善口服葡萄糖耐量、空腹血糖、甘油三酯、非酯化脂肪酸浓度和血压。因此，寒战的冷驯化可能代表了预防和治疗肥胖相关代谢紊乱的另一种生活方式。ClinicalTrials.gov 注册：NCT04516018。