The metabolic sensor enzyme OGT dynamically O-GlcNAcylates hexokinase 1 (HK1). This modification enhances the localization of HK1 to mitochondria in response to glucose flux and facilitates the formation of a glycolytic metabolon on the mitochondrial outer membrane, leading to increased rates of both glycolytic and mitochondrial ATP production.

中文翻译：

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O-GlcNAc 转移酶调节线粒体上糖酵解代谢的形成以增强 ATP 产生


代谢传感器酶 OGT 动态 O-GlcNAc 酰化己糖激酶 1 (HK1)。这种修饰增强了 HK1 对葡萄糖通量的响应而定位到线粒体，并促进线粒体外膜上糖酵解代谢的形成，从而导致糖酵解和线粒体 ATP 生成率增加。