Neurodevelopment involves the migration, projection, and integration of various cell types across different regions of the nervous system. Assembloids are self-organizing systems formed by the integration of multiple organoids or cell types. Here, we outline the generation and application of assembloids. We illustrate how assembloids recapitulate critical neurodevelopmental steps, like migration, axon projection, and circuit formation, and how they are starting to provide biological insights into neuropsychiatric disorders. Additionally, we review how assembloids can be used to study properties emerging from cell-cell interactions within non-neural tissues. Overall, assembloid platforms represent a powerful tool for discovering human biology and developing therapeutics.

中文翻译：

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用于研究组织和疾病生物学的细胞间相互作用的组装模型


神经发育涉及各种细胞类型在神经系统不同区域的迁移、投射和整合。组装体是由多种类器官或细胞类型整合而成的自组织系统。在这里，我们概述了集合体的产生和应用。我们说明了组合体如何概括关键的神经发育步骤，如迁移、轴突投射和回路形成，以及它们如何开始为神经精神疾病提供生物学见解。此外，我们回顾了如何使用组装体来研究非神经组织内细胞间相互作用中出现的特性。总体而言，组装平台是发现人类生物学和开发治疗方法的强大工具。