The use of stem cells to model the early human embryo promises to transform our understanding of developmental biology and human reproduction. In this review, we present our current knowledge of the first 2 weeks of human embryo development. We first focus on the distinct cell lineages of the embryo and the derivation of stem cell lines. We then discuss the intercellular crosstalk that guides early embryo development and how this crosstalk is recapitulated in vitro to generate stem cell-based embryo models. We highlight advances in this fast-developing field, discuss current limitations, and provide a vision for the future.

中文翻译：

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早期人类发育和基于干细胞的人类胚胎模型


使用干细胞来模拟早期人类胚胎有望改变我们对发育生物学和人类生殖的理解。在这篇综述中，我们介绍了我们目前对人类胚胎发育前两周的了解。我们首先关注胚胎的不同细胞谱系和干细胞系的衍生。然后，我们讨论指导早期胚胎发育的细胞间串扰，以及如何在体外重现这种串扰以生成基于干细胞的胚胎模型。我们重点介绍这个快速发展领域的进展，讨论当前的局限性，并提供未来的愿景。