CD54 and CD58 are adhesion proteins that mediate efficient immune synapse formation. Hammer et al. now show that the abrogation of these molecules in T and NK cells prevents their immune rejection while maintaining their effector function. These findings should significantly help advance our efforts to generate “off-the-shelf” allogeneic products.

中文翻译：

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一种介导同种异体免疫细胞疗法的单向街道识别方法


CD54 和 CD58 是介导有效免疫突触形成的粘附蛋白。哈默等人。现在表明，T 细胞和 NK 细胞中这些分子的消除可以防止其免疫排斥，同时保持其效应功能。这些发现应该会极大地帮助推进我们生产“现成的”同种异体产品的努力。