Bacteria often defend against phage infection by deploying NADase effectors to degrade cellular NAD⁺, thereby halting both bacterial growth and phage replication. In a recent article in Nature, Osterman et al.¹ identify phage-encoded counterdefense pathways that reconstitute NAD⁺ during infection, enabling phages to combat multiple unrelated antiphage systems.

中文翻译：

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噬菌体在 NAD+ 的代谢军备竞赛中占据上风


细菌通常通过部署 NADase 效应子来降解细胞 NAD⁺，从而阻止细菌生长和噬菌体复制，从而抵御噬菌体感染。在最近发表在《自然》杂志上的一篇文章中，Osterman 等人¹ 确定了噬菌体编码的反防御途径，这些途径在感染过程中重组 NAD⁺，使噬菌体能够对抗多个不相关的抗噬菌体系统。