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5H7c: A rabbit monoclonal antibody detecting ferroptotic cells
Molecular Cell ( IF 14.5 ) Pub Date : 2024-12-05 , DOI: 10.1016/j.molcel.2024.11.001
Shaojie Cui, Linda Donnelly, Anchal Ghai, Samuel Achilefu, Jin Ye

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Ferroptosis, a cell death pathway triggered by iron-catalyzed peroxidation of phospholipids, has been implicated in both disease progression and cancer treatment.1 A major challenge in studying ferroptosis has been the difficulty in detecting ferroptotic cells under physiological conditions, owing to the lack of a specific marker for ferroptosis.1 This obstacle was recently overcome by our study published in Molecular Cell, which identified hyperoxidized PRDX3 as a specific marker for

Declaration of interests

The authors declare no competing interests.


中文翻译:


5H7c:检测铁死亡细胞的兔单克隆抗体


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铁死亡是一种由铁催化的磷脂过氧化触发的细胞死亡途径,与疾病进展和癌症治疗有关。1 研究铁死亡的一个主要挑战是由于缺乏铁死亡的特异性标志物,在生理条件下难以检测铁死亡细胞。1 我们最近发表在《分子细胞》上的研究克服了这一障碍,该研究确定高氧化 PRDX3 是

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作者声明没有利益冲突。
更新日期:2024-12-05
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