The regulatory mechanisms of silencers have remained poorly understood. In this issue, Hofbauer et al.¹ conduct a genome-wide screen in Drosophila melanogaster and reveal three silencer types that appear to work alone—without the need for combinatorial action, traditional chromatin marks, or open chromatin regions.

中文翻译：

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静音消音器：不留痕迹


消音器的调节机制仍然知之甚少。在本期中，Hofbauer 等人1 对黑腹果蝇进行了全基因组筛选，并揭示了三种似乎单独起作用的沉默剂类型，无需组合作用、传统染色质标记或开放染色质区域。