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LncRNAs chaperoning dynamic protein condensates in cancer cells
Molecular Cell ( IF 14.5 ) Pub Date : 2024-12-19 , DOI: 10.1016/j.molcel.2024.11.028
Jiaojiao Hu, Dan Li, Cong Liu

In this issue of Molecular Cell, Sun et al. reveal that the long non-coding RNA (lncRNA) DNAJC3-AS1 plays a dual role in maintaining the rRNA processing function of fibrillarin (FBL) in cancer cells. It promotes FBL condensation while preventing abnormal aggregation, offering new therapeutic insights for cancer treatment by targeting lncRNAs involved in the regulation of FBL condensation.

中文翻译:


LncRNA 陪伴癌细胞中的动态蛋白质凝聚物



在本期 Molecular Cell 中,Sun 等人揭示了长链非编码 RNA (lncRNA) DNAJC3-AS1 在维持癌细胞中原纤维蛋白 (FBL) 的 rRNA 加工功能中起着双重作用。它促进 FBL 凝聚,同时防止异常聚集,通过靶向参与 FBL 凝聚调节的 lncRNA 为癌症治疗提供新的治疗见解。
更新日期:2024-12-19
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