Readily available nutrient-rich foods exploit our inherent drive to overconsume, creating an environment of overnutrition. This transformative setting has led to persistent health issues, such as obesity and metabolic syndrome. The development of glucagon-like peptide-1 receptor (GLP-1R) agonists reveals our ability to pharmacologically manage weight and address metabolic conditions. Obesity is directly linked to chronic low-grade inflammation, connecting our metabolic environment to neurodegenerative diseases. GLP-1R agonism in curbing obesity, achieved by impacting appetite and addressing associated metabolic defects, is revealing additional benefits extending beyond weight loss. Whether GLP-1R agonism directly impacts brain health or does so indirectly through improved metabolic health remains to be elucidated. In exploring the intricate connection between obesity and neurological conditions, recent literature suggests that GLP-1R agonism may have the capacity to shape the neurovascular landscape. Thus, GLP-1R agonism emerges as a promising strategy for addressing the complex interplay between metabolic health and cognitive well-being.

中文翻译：

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GLP-1 对神经血管景观进行编程


现成的营养丰富的食物利用了我们固有的过度消费驱动力，创造了一个营养过剩的环境。这种变革性的环境导致了持续的健康问题，例如肥胖和代谢综合征。胰高血糖素样肽-1 受体 （GLP-1R） 激动剂的开发揭示了我们药理学控制体重和解决代谢状况的能力。肥胖与慢性低度炎症直接相关，将我们的代谢环境与神经退行性疾病联系起来。GLP-1R 通过影响食欲和解决相关的代谢缺陷来抑制肥胖，揭示了超越减肥的其他益处。GLP-1R 激动剂是直接影响大脑健康还是通过改善代谢健康间接影响大脑健康仍有待阐明。在探索肥胖与神经系统疾病之间的复杂联系时，最近的文献表明 GLP-1R 激动剂可能具有塑造神经血管景观的能力。因此，GLP-1R 激动剂成为解决代谢健康和认知健康之间复杂相互作用的一种有前途的策略。