Organismal aging involves several hallmark pathways, including chronic inflammation and metabolic dysfunction. However, the origin of age-related inflammation is incompletely understood. In a recent study published in Nature,¹ Widjaja et al. show that blocking the age-related increase in IL-11 restores immune-metabolic homeostasis and extends healthspan and lifespan in mice.

中文翻译：

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通过抑制炎症对抗“IL-11ness”：健康和长寿的策略

机体衰老涉及多种标志性途径，包括慢性炎症和代谢功能障碍。然而，与年龄相关的炎症的起源尚不完全清楚。在《自然》杂志最近发表的一项研究中， ¹ Widjaja 等人。研究表明，阻断与年龄相关的 IL-11 增加可以恢复小鼠的免疫代谢稳态，并延长小鼠的健康寿命和寿命。