Episodic memory is organized in both spatial and temporal contexts. The hippocampus is crucial for episodic memory and has been demonstrated to encode spatial and temporal information. However, how the representations of space and time interact in the hippocampal memory system is still unclear. Here, we recorded the activity of hippocampal CA1 neurons in mice in a variety of one-dimensional navigation tasks while systematically varying the speed of the animals. For all tasks, we found neurons simultaneously represented space and elapsed time. There was a negative correlation between the preferred space and lap duration, e.g., the preferred spatial position shifted more toward the origin when the lap duration became longer. A similar relationship between the preferred time and traveled distance was also observed. The results strongly suggest a competitive and integrated representation of space-time by single hippocampal neurons, which may provide the neural basis for spatiotemporal contexts.

中文翻译：

---

海马体中空间与时间的整合与竞争


情景记忆在空间和时间背景下都有组织。海马体对于情景记忆至关重要，并已被证明可以编码空间和时间信息。然而，空间和时间的表示如何在海马记忆系统中相互作用仍不清楚。在这里，我们记录了小鼠海马 CA1 神经元在各种一维导航任务中的活动，同时系统地改变了动物的速度。对于所有任务，我们发现神经元同时代表空间和经过的时间。首选空间和单圈持续时间之间存在负相关，例如，当单圈持续时间变长时，首选空间位置更偏向原点。还观察到首选时间和行驶距离之间的类似关系。结果强烈表明单个海马神经元对时空的竞争和综合表示，这可能为时空背景提供神经基础。