The role of experience in the organization of cortical feedback (FB) remains unknown. We measured the effects of manipulating visual experience on the retinotopic specificity of supragranular and infragranular projections from the lateromedial (LM) visual area to layer (L)1 of the mouse primary visual cortex (V1). LM inputs were, on average, retinotopically matched with V1 neurons in normally and dark-reared mice, but visual exposure reduced the fraction of spatially overlapping inputs to V1. FB inputs from L5 conveyed more surround information to V1 than those from L2/3. The organization of LM inputs from L5 depended on their orientation preference and was disrupted by dark rearing. These observations were recapitulated by a model where visual experience minimizes receptive field overlap between LM inputs and V1 neurons. Our results provide a mechanism for the dependency of surround modulations on visual experience and suggest how expected interarea coactivation patterns are learned in cortical circuits.

中文翻译：

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视觉体验减少了皮层反馈输入和初级视觉皮层神经元之间的空间冗余


经验在皮层反馈 （FB） 组织中的作用仍然未知。我们测量了操纵视觉体验对从外侧内侧 （LM） 视觉区域到小鼠初级视觉皮层 （V1） 第 （L） 层 （L）1 的颗粒上和颗粒下投射的视网膜特异性的影响。平均而言，LM 输入与正常和深色饲养小鼠的 V1 神经元视网膜匹配，但视觉暴露降低了 V1 的空间重叠输入的比例。来自 L5 的 FB 输入比来自 L2/3 的输入向 V1 传达了更多的环绕信息。来自 L5 的 LM 输入的组织取决于它们的方向偏好，并被暗饲养打乱。这些观察结果由一个模型概括，其中视觉体验最大限度地减少了 LM 输入和 V1 神经元之间的感受野重叠。我们的结果为周围调制对视觉体验的依赖性提供了一种机制，并表明了如何在皮层回路中学习预期的区域间共激活模式。