Striatum and its predominant input, motor cortex, are responsible for the selection and performance of purposive movement, but how their interaction guides these processes is not understood. To establish its neural and behavioral contributions, we bilaterally lesioned motor cortex and recorded striatal activity and reaching performance daily, capturing the lesion’s direct ramifications within hours of the intervention. We observed reaching impairment and an absence of striatal motoric activity following lesion of motor cortex, but not parietal cortex control lesions. Although some aspects of performance began to recover after 8–10 days, striatal projection and interneuronal dynamics did not—eventually entering a non-motor encoding state that aligned with persisting kinematic control deficits. Lesioned mice also exhibited a profound inability to switch motor plans while locomoting, reminiscent of clinical freezing of gait (FOG). Our results demonstrate the necessity of motor cortex in generating trained and untrained actions as well as striatal motoric dynamics.

中文翻译：

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运动皮层负责纹状体的运动动力学以及熟练和非熟练动作的执行


纹状体及其主要输入运动皮层负责有目的的运动的选择和执行，但它们的相互作用如何指导这些过程尚不清楚。为了确定其神经和行为贡献，我们对双侧损伤运动皮层进行了损伤，并记录了纹状体活动和每天达到的表现，在干预后的数小时内捕捉了损伤的直接影响。我们观察到运动皮层损伤后触及障碍和纹状体运动活动的缺失，但没有观察到顶叶皮层控制病变。尽管性能的某些方面在 8-10 天后开始恢复，但纹状体投射和神经元间动力学却没有——最终进入与持续运动控制缺陷一致的非运动编码状态。病变小鼠在移动时也表现出极度无法切换运动计划，让人想起临床步态冻结 （FOG）。我们的结果表明，运动皮层在产生经过训练和未经训练的动作以及纹状体运动动力学方面的必要性。