In this issue of Neuron, Chen et al.1 found that lateral septum Esr1-expressing cells respond to both non-drug and drug rewards. Mice will lever press for optogenetic stimulation of these neurons, which are also critical to methamphetamine locomotor sensitization, conditioned place preference, self-administration, and reinstatement.

中文翻译：

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侧隔膜重返大脑奖励的中心舞台


在本期《Neuron》中，Chen 等人1 发现侧隔膜表达 Esr1 的细胞对非药物和药物奖励都有反应。小鼠会通过杠杆压力对这些神经元进行光遗传学刺激，这对于甲基苯丙胺运动敏化、条件性位置偏好、自我给药和恢复也至关重要。