In this issue of Cancer Cell, Qiu et al. use single-cell metabolic analysis to identify reduced mannose metabolism as a previously unknown feature of exhausted T cells. This metabolic pathway can be targeted to enhance memory and persistence of adoptively transferred T cells, resulting in improved anti-tumor efficacy.

中文翻译：

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改善过继细胞治疗的代谢途径


在本期 Cancer Cell 中，Qiu 等人使用单细胞代谢分析来确定甘露糖代谢减少是耗竭 T 细胞以前未知的特征。这种代谢途径可以靶向增强过继转移的 T 细胞的记忆和持久性，从而提高抗肿瘤疗效。