Errors in chromosome segregation during cell division lead to changes in nuclear features. A study now shows that a mechanosensitive nuclear checkpoint activates the tumour suppressor p53 to halt the proliferation of aneuploid cells. These findings provide mechanistic insights to explore in both ageing and cancer pathologies.

中文翻译：

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机械师检查畸形染色体


细胞分裂过程中染色体分离的错误会导致核特征的变化。现在的一项研究表明，机械敏感的核检查点激活肿瘤抑制因子 p53 以阻止非整倍体细胞的增殖。这些发现为探索衰老和癌症病理学提供了机制见解。