Unconventional T cells, including invariant natural killer T (iNKT) cells, gamma delta (γδ) T cells, and mucosal-associated invariant T (MAIT) cells, play important roles in both innate and adaptive immunity. These cells respond to tumors rapidly and influence the tumor microenvironment (TME). Recent advances in understanding their biology, as well as the development of novel therapeutic approaches, have underscored their potential in cancer immunotherapy. This commentary will assess these advances and translational possibilities in the field.

中文翻译：

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打破常规：癌症治疗中的非常规 T 细胞


非常规 T 细胞，包括不变自然杀伤 T （iNKT） 细胞、γδ （γδ） T 细胞和粘膜相关不变 T 细胞 （MAIT） 细胞，在先天免疫和适应性免疫中都起着重要作用。这些细胞对肿瘤反应迅速并影响肿瘤微环境 （TME）。最近在了解其生物学方面取得的进展以及新型治疗方法的开发强调了它们在癌症免疫治疗中的潜力。本评论将评估该领域的这些进展和转化可能性。