In a recently published article in Nature, Bayly-Jones et al. report the cryo-EM structures of a lysosomal cholesterol sensor, LYCHOS, also known as GPR155, which reveals a unique fusion of a plant auxin-transporter-like domain with a seven-transmembrane GPCR-like domain and elucidates mechanistic insights into cellular regulation of mTORC1 activity.

中文翻译：

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被对胆固醇的热爱所束缚：转运蛋白遇上 GPCR


在最近发表在《自然》杂志上的一篇文章中，Bayly-Jones 等人报道了溶酶体胆固醇传感器 LYCHOS（也称为 GPR155）的冷冻电镜结构，它揭示了植物生长素转运蛋白样结构域与七次跨膜 GPCR 样结构域的独特融合，并阐明了 mTORC1 活性的细胞调控机制见解。