Cryo-electron microscopy structures of paenilamicin-stalled ribosomes showed that it has a unique ribosome-binding site located between the A- and P-site tRNAs. Additional biochemical assays demonstrated that paenilamicins inhibit protein synthesis by blocking the movement of mRNA and tRNA through the ribosome during the elongation phase.

中文翻译：

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Paenilamicins 与核糖体上的独特位点结合以抑制蛋白质合成


泛烯胺霉素停滞核糖体的冷冻电子显微镜结构显示，它具有位于 A 位点和 P 位点 tRNA 之间的独特核糖体结合位点。其他生化测定表明，泛烯胺素通过在延伸阶段阻断 mRNA 和 tRNA 通过核糖体的运动来抑制蛋白质合成。