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Sweet RNA
Nature Chemical Biology ( IF 12.9 ) Pub Date : 2024-09-18 , DOI: 10.1038/s41589-024-01746-7 Yiyun Song 1
更新日期：2024-09-18
Nature Chemical Biology ( IF 12.9 ) Pub Date : 2024-09-18 , DOI: 10.1038/s41589-024-01746-7 Yiyun Song 1
Affiliation
By coupling rPAL to enzymatic glycan cleavage and sequential window acquisition of all theoretical mass spectra (SWATH-MS), the team found that acp3U was the most enriched linker (although other putative linker substrates were identified). Importantly, knocking out DTWD2, an enzyme responsible for installing acp3U in tRNAs, reduced glycoRNA levels. This study provides not only a useful tool for glycoRNA detection, but also the first direct evidence of a covalent linkage between a secretory N-glycan and RNA, paving the way for future functional studies.
Original reference: Cell https://doi.org/10.1016/j.cell.2024.07.044 (2024)
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