Covalent modification of cysteine by electrophilic small molecules enables broad targeting of the unliganded proteome. A study reveals that cysteine reactive electrophiles can induce widespread degradation of host proteins and remodeling of cellular proteostasis at commonly used concentrations.

中文翻译：

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亲电试剂的压力


亲电小分子对半胱氨酸的共价修饰能够广泛靶向未配体的蛋白质组。一项研究表明，半胱氨酸反应性亲电试剂可在常用浓度下诱导宿主蛋白的广泛降解和细胞蛋白质稳态的重塑。