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Cracking the diversity of sweet drugs
Nature Chemical Biology ( IF 12.9 ) Pub Date : 2024-10-24 , DOI: 10.1038/s41589-024-01755-6
Sharon Yehuda, Vered Padler-Karavani

Characterization of the heterogeneity in the glycosylation of biotherapeutics is crucial for drug development but challenging. Now, an approach allows the rapid analysis of the glycosylation of intact glycoproteins, without prior processing or separation, enabling the study of glycan composition and quality assessment of any glycoprotein drug.

中文翻译:


破解甜食药物的多样性



表征生物治疗药物糖基化的异质性对于药物开发至关重要,但也具有挑战性。现在,一种方法允许快速分析完整糖蛋白的糖基化,而无需事先处理或分离,从而能够研究任何糖蛋白药物的糖组成和质量评估。
更新日期:2024-10-24
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