Lasso peptides are naturally produced interlocked molecules that hold promise for the design of stable peptide-based therapeutics. Recent predictions of enzyme–substrate interactions suggest a conserved binding pocket and enable the engineering of mutant lasso cyclases that broaden substrate tolerance.

中文翻译：

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大自然如何系上肽结


套索肽是天然产生的互锁分子，有望设计用于设计稳定的基于肽的疗法。最近对酶-底物相互作用的预测表明存在保守的结合口袋，并能够设计出扩大底物耐受性的突变套索环化酶。