Phospholipid distribution across the lipid bilayer of plasma membranes is critical for various cellular functions. A genome-wide screen and structural analysis identified TMEM63B as a membrane structure-responsive lipid scramblase. In response to changes in membrane structure, TMEM63B alters its conformation and translocates phospholipids, thereby controlling plasma membrane lipid distribution.

中文翻译：

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TMEM63B 扰乱磷脂以响应膜结构的变化


磷脂分布在质膜脂质双层中对各种细胞功能至关重要。全基因组筛选和结构分析确定TMEM63B为膜结构反应性脂质扰乱酶。响应膜结构的变化，TMEM63B 改变其构象并易位磷脂，从而控制质膜脂质分布。