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The guanylate-binding protein GBP1 forms a protein coat that enwraps cytosol-invasive bacteria
Nature Structural & Molecular Biology ( IF 12.5 ) Pub Date : 2024-10-15 , DOI: 10.1038/s41594-024-01403-6
Nature Structural & Molecular Biology ( IF 12.5 ) Pub Date : 2024-10-15 , DOI: 10.1038/s41594-024-01403-6
GBP1 is an important innate immunity component that contributes to the control of cytosol-invasive bacterial pathogens. Using cryo-electron microscopy (cryo-EM), cryo-electron tomography (cryo-ET) and biophysical assays, we show how GBP1 oligomers enwrap and remodel the lipopolysaccharide (LPS)-containing membrane of gram-negative bacterial pathogens.
中文翻译:
鸟苷酸结合蛋白 GBP1 形成包裹胞质溶胶侵袭细菌的蛋白质外壳
GBP1 是一种重要的先天免疫成分,有助于控制胞质溶胶侵袭性细菌病原体。使用冷冻电子显微镜 (cryo-EM)、冷冻电子断层扫描 (cryo-ET) 和生物物理测定,我们展示了 GBP1 寡聚体如何包裹和重塑含脂多糖 (LPS) 的革兰氏阴性细菌病原体膜。
更新日期:2024-10-16
中文翻译:
鸟苷酸结合蛋白 GBP1 形成包裹胞质溶胶侵袭细菌的蛋白质外壳
GBP1 是一种重要的先天免疫成分,有助于控制胞质溶胶侵袭性细菌病原体。使用冷冻电子显微镜 (cryo-EM)、冷冻电子断层扫描 (cryo-ET) 和生物物理测定,我们展示了 GBP1 寡聚体如何包裹和重塑含脂多糖 (LPS) 的革兰氏阴性细菌病原体膜。