Autoantibodies targeting glutamatergic N-methyl-d-aspartic acid receptors (NMDARs) are found in people with anti-NMDAR encephalitis. Two studies reveal that patient-derived autoantibodies are diverse in their epitope binding and modes of action on the NMDAR, providing insights into the mechanisms behind autoantibody-induced NMDAR hypofunction.

中文翻译：

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来自脑炎个体的多种抗 NMDAR 自身抗体


在抗 NMDAR 脑炎患者中发现了靶向谷氨酸能 N-甲基-d-天冬氨酸受体 （NMDAR） 的自身抗体。两项研究表明，患者来源的自身抗体在表位结合和对 NMDAR 的作用方式方面多种多样，为自身抗体诱导的 NMDAR 功能减退背后的机制提供了见解。