Racetam anticonvulsants, such as levetiracetam, are widely prescribed to treat and prevent seizures. Despite decades of clinical use, their mechanism of action remains unclear. Two studies now reveal the structure of the racetam-binding protein SV2A in complex with anticonvulsant drugs, providing insights into their mechanism of action and the physiology of neurotransmission.

中文翻译：

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SV2A 和外消旋抗惊厥药机制的结构见解


外消旋坦抗惊厥药，如左乙拉西坦，被广泛用于治疗和预防癫痫发作。尽管临床使用数十年，但它们的作用机制仍不清楚。现在有两项研究揭示了外消旋结合蛋白 SV2A 与抗惊厥药物复合物的结构，为它们的作用机制和神经传递的生理学提供了见解。