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ScopeThis multi‐omic study investigates the bidirectional interactions between gut microbiota and silymarin metabolism, highlighting the differential effects across various age groups. Silymarin, the extract from Silybum marianum (milk thistle), is commonly used for its hepatoprotective effects.Methods and resultsAn in vitro fermentation colon model was used with microbiota from 20 stool samples obtained

ScopeAcute alcoholic liver injury (AALI), a global health concern, is exacerbated by excessive episodic drinking. L‐theanine (LTA), a compound found in tea leaves, mitigates the AALI‐induced liver oxidative stress and inflammation. However, its relationship with alcohol metabolism and its liver‐protective mechanism remains unexplored.Methods and resultsThis study investigates the protective mechanisms

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ScopeHair loss is a common problem that can negatively impact individuals' psychological well‐being. Androgenetic alopecia (AGA) is one of the most prevalent types of nonscarring hair loss. This review summarizes the existing evidence on the relationship between AGA and various micronutrients, including vitamin B, vitamin D, vitamin A, vitamin C, iron, selenium, zinc, manganese, and copper.MethodsA

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Key Message Synthetic cannabinoids are an increasingly widespread drug of concern. Given their toxicity and newfound ubiquity, psychiatrists need to be able to manage their adverse effects. They have been linked to exacerbation of certain psychiatric conditions, and we highlight a unique case where neuroleptic malignant syndrome was associated with this. Learning Points All patients who require antipsychotics

Antidepressants used by patients with bipolar disorder have been associated with destabilization with an increase in mania, depression, and cycling. The most commonly proposed mechanism, that antidepressants ‘overshoot’ their antidepressant effect to create a manic or mixed state, is unlikely since antidepressants have actually been found to be ineffective in treating bipolar depression. Beginning

CONFLICT OF INTEREST STATEMENT Dr. El-Mallakh is a speaker for Axsome, Intracellular, Janssen, Lundbeck, Noven, Otsuka, and Vanda. None of the other authors have potential conflicts of interest.