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Coffee Bioactive N-Methylpyridinium: Unveiling Its Antilipogenic Effects by Targeting De Novo Lipogenesis in Human Hepatocytes
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2024-10-06 , DOI: 10.1002/mnfr.202400338
Laura Giannotti, Eleonora Stanca, Benedetta Di Chiara Stanca, Francesco Spedicato, Marika Massaro, Stefano Quarta, Daniele Del Rio, Pedro Mena, Luisa Siculella, Fabrizio Damiano

Type 2 diabetes and nonalcoholic fatty liver diseases (NAFLDs) are promoted by insulin resistance (IR), which alters lipid homeostasis in the liver. This study aims to investigate the effect of N-methylpyridinium (NMP), a bioactive alkaloid of coffee brew, on lipid metabolism in hepatocytes.

中文翻译:


咖啡生物活性 N-甲基吡啶:通过靶向人肝细胞中的从头脂肪生成揭示其抗脂作用



胰岛素抵抗 (IR) 会促进 2 型糖尿病和非酒精性脂肪性肝病 (NAFLD),胰岛素抵抗会改变肝脏中的脂质稳态。本研究旨在探讨咖啡冲泡中的生物活性生物碱 N-甲基吡啶 (NMP) 对肝细胞脂质代谢的影响。
更新日期:2024-10-06
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