ScopeWe aim to assess the interaction between genetic risk and magnesium (Mg) intake during pregnancy on the development of gestational diabetes mellitus (GDM).Methods and resultsThree thousand ninety‐six pregnant women from Tongji Maternal and Child Health Cohort are involved in our study. One hundred twelve susceptibility genetic variants of diabetes are selected and genotyped through Asian Screening Array bead chip. Mg intake were assessed by a validated food frequency questionnaire conducted at gestational weeks 25.1 ± 2.7 before GDM diagnosis. The study identifies 22 variants associated with GDM. Weighted genetic risk score (GRS) based on these 22 SNPs is associated with higher occurrence of GDM. There is an interaction between GRS and Mg intake on GDM risk (p‐interaction = 0.019). Pregnant women with high GRS (≥23.48) and insufficient Mg intake (<370.0 mg d−1) have a 1.74 (95% confidence interval [CI]: 1.02, 2.98) fold risk of GDM after adjusting for potential confounders. No such relationship exists among pregnant women with low GRS (<23.48) (adjusted relative risk [RR] = 1.18; 95% CI: 0.73, 1.92).ConclusionGenetic predisposition to GDM is modified by Mg intake. This suggests that clinical nutrition guidance may benefit from being tailored by screening women with high diabetic genetic risk.

中文翻译：

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膳食镁摄入量与遗传风险评分对妊娠糖尿病风险的交互作用


范围我们旨在评估遗传风险与怀孕期间镁 （Mg） 摄入量对妊娠糖尿病 （GDM） 发展的相互作用。方法和结果来自同济市妇幼保健队列的 396 名孕妇参与了我们的研究。通过 Asian Screening Array 微珠芯片选择 112 种糖尿病易感遗传变异并进行基因分型。通过在 GDM 诊断前孕周 25.1 ± 2.7 周进行的经过验证的食物频率问卷评估 Mg 摄入量。该研究确定了 22 个与 GDM 相关的变异。基于这 22 个 SNP 的加权遗传风险评分 （GRS） 与 GDM 的发生率较高相关。GRS 和 Mg 摄入量对 GDM 风险存在交互作用 （p-交互作用 = 0.019）。GRS 高 （≥23.48） 和 Mg 摄入不足 （<370.0 mg d-1） 的孕妇在调整潜在混杂因素后患 GDM 的风险是 1.74 倍 （95% 置信区间 [CI]： 1.02， 2.98） 倍。在低 GRS 孕妇 （<23.48） 中不存在这种关系 （校正相对风险 [RR] = 1.18;95% CI： 0.73， 1.92）。结论GDM 的遗传易感性受 Mg 摄入的影响。这表明，通过筛查糖尿病遗传风险高的女性来定制临床营养指南可能会受益。