ScopeThe intestinal flora is involved in the maintenance of human health and the development of diseases, and is closely related to the brain. As an essential amino acid, tryptophan (TRP) participates in a variety of physiological functions in the body and affects the growth and health of the human body. TRP catabolites produced by the gut microbiota are important signaling molecules for microbial communities and host–microbe interactions, and play an important role in maintaining health and disease pathogenesis.Methods and resultsThe review first demonstrates the evidence of TRP metabolism in stroke and the relationship between gut microbiota and TRP metabolism. Furthermore, the review reveals that food homologous plants (FHP) bioactive compounds have been shown to regulate various metabolic pathways of the gut microbiota, including the biosynthesis of valine, leucine, isoleucine, and vitamin B6 metabolism. The most notable metabolic alteration is in TRP metabolism.ConclusionThe interaction between gut microbiota and TRP metabolism offers a plausible explanation for the notable bioactivities of FHP in the treatment of ischemic stroke (IS). This review enhances the comprehension of the underlying mechanisms associated with the bioactivity of FHP on IS.

中文翻译：

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肠道菌群和色氨酸代谢在缺血性脑卒中发病机制中的作用：食物同源植物的潜在作用


范围肠道菌群参与维持人体健康和疾病的发展，与大脑密切相关。色氨酸 （TRP） 作为一种必需氨基酸，参与体内的多种生理功能，影响人体的生长和健康。肠道微生物群产生的 TRP 分解代谢物是微生物群落和宿主-微生物相互作用的重要信号分子，在维持健康和疾病发病机制中发挥着重要作用。方法和结果本综述首先证明了中风中 TRP 代谢的证据以及肠道菌群与 TRP 代谢之间的关系。此外，该综述揭示了食品同源植物 （FHP） 生物活性化合物已被证明可以调节肠道微生物群的各种代谢途径，包括缬氨酸、亮氨酸、异亮氨酸和维生素 B6 代谢的生物合成。最显着的代谢改变是 TRP 代谢。结论肠道菌群与 TRP 代谢之间的相互作用为 FHP 治疗缺血性卒中 （IS） 中显着的生物活性提供了合理的解释。本综述增强了对与 FHP 对 IS 的生物活性相关的潜在机制的理解。