G-quadruplexes (G4s) are potential drug targets in cancer treatment. However, the G4-targeted ligands seem to be lack of enough selectivity between tumors and normal tissues, appealing for more precise therapeutic strategies. Type-1 photodynamic therapy (PDT) is a promising strategy possessing excellent spatiotemporal precision for solid tumors with hypoxic microenvironment. However, rational design

NO2 is a toxic gas that poses a significant threat to the environment and human health. In this work, we studied the ultra-high NO2 sensitivity of lanthanum (La)-doped ZnO porous nanocages. La doping into ZnO via a simple one-step co-precipitation MOF encapsulation-calcination route resulted in a significant improvement in NO2 sensing performance. This study focused on doping ZnO with 2%, 4%, and 8%

The emergence of multifunctional wearable flexible sensors has propelled advancements in healthcare and outdoor sports. However, conventional aerogels used for multifunctional sensing often involve complex fabrication processes, lack durability, and struggle to achieve collaborative sensing in complex scenarios, sometimes even lacking conductivity. This paper presents a novel strategy for synthesizing

The adsorption of nonspecific biomolecules on sensing surfaces presents a challenge for accurate and sensitive detection of targets in complex biological samples, which significantly restricts the practical application of biosensors. It is therefore crucial to develop sensing devices with antifouling capabilities. Herein, a low fouling electrochemical biosensing platform has been developed that leverage

Excessive residues of nitrite can pose a serious threat to human health, making the establishment of an efficient and effective electrochemical sensor for nitrite detection highly necessary. Herein, we report on a sensor based on nitrogen-doped carbon nanofibers, with FeCoNiCuAl high-entropy alloy (HEAs) nanoparticles in situ grown on the carbon fibers through a confinement effect. The FeCoNiCuAl/CNFs

The ratiometric sensing strategy with dual-signal output drastically compensates for the background noise and interference from the detection environment of the sensing method with a single-signal output. However, the stability of the reference signal has become the primary challenge in constructing a ratio detection sensor. Therefore, in order to realize stable ratio signal sensing detection, methylene

Hydrocephalus is a neurological disorder characterized by the accumulation of cerebrospinal fluid (CSF) in the brain, resulting in increased intracranial pressure and potentially life-threatening complications. Conventional treatment is CSF shunt implantation but, particularly in pediatric patients, this is fraught with high failure rates of 40% at 2 years and 98% at 10 years. In pursuit of improving

Being one of the most extensively researched and widely used thermostable DNA polymerases, Taq DNA polymerase derived from Thermus aquaticus has played pivotal roles in numerous molecular biology applications. The accurate and convenient determination of enzymatic activity is a fundamental prerequisite for both academic research and the industrial application of Taq DNA polymerase. To address the limitations

Serum levels of leukocyte cell-derived chemotaxin-2 (LECT2) have emerged as promising diagnostic biomarker for liver fibrosis. Targeting the LECT2/Tie1 signaling pathway holds potential for innovative treatment approaches to this condition. Despite this, the development of highly sensitive assays for serum LECT2 remains limited. Surface plasmon resonance (SPR), a label-free technique for detecting

Surface-enhanced Raman spectroscopy (SERS) has been applied in many analytical fields owing to its features like single molecule sensitivity and fingerprint identification. To face the challenges in detecting large molecules, developing gap-free SERS substrates with excellent performance as well as desired electromagnetic (EM) field distribution is receiving increasing attentions. Herein, we propose

An UV-activated TiO2/SnO2 thin-film oxygen sensor was fabricated by simple sputtering deposition and thermal annealing. It was found that introducing TiO2 film can obviously increase the response speed of the sensor (∼ 2 fold increase with 20 nm TiO2 introducing). Moreover, it was found that introducing TiO2 would lead to the formation of orthorhombic phase of SnO2, due to the dissolution of Ti into

NH3 is a fairly important raw material in a number of fields but harmful to the human. Currently, hydrogen substituted graphyne (HsGY) shows fast response to NH3 gas based on our previous report. However, it still suffers from low response values and humidity interference. CeO2 has the advantage of moisture resistance as NH3 gas sensor but prone to agglomeration, whereas the alkyne bond of HsGY can

Fibre optic probe based Raman spectroscopy can deliver in vivo molecular compositional analysis of a range of diseases. However, some biological tissues exhibit high levels of fluorescence which limit the utility of the technique, particularly when the fluorescence induces CCD etaloning, which can be particulalry hard to remove in subsequent analysis. Furthermore, use of fibre probes can result in