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Rational Design of the First Dual Agonist at Trace Amine-Associated Receptor 1 and 5-HT2C Receptors Based on Binding Pocket Similarity for the Treatment of Schizophrenia and Alzheimer’s Disease-Related Psychosis J. Med. Chem. (IF 6.8) Pub Date : 2025-03-31
Jing Lu, Pengfei Yu, Yunjie Wang, Yusen Dai, Wenyan Wang, Chunjiao Liu, Lin Dong, Hui Lei, Yifei Yang, Lin Wang, Fangxia Zou, Xuan Deng, Bingsi Wang, Shujuan Wei, Mingxu Ma, Hongbo Wang, Liang Ye, Jianzhao Zhang, Jingwei Tian -
Reversible Small Molecule Multivariant Ras Inhibitors Display Tunable Affinity for the Active and Inactive Forms of Ras J. Med. Chem. (IF 6.8) Pub Date : 2025-03-31
Charles W. Parry, Francesca Pellicano, Alexander W. Schüttelkopf, Kim S. Beyer, Justin Bower, Amy Bryson, Kenneth Cameron, Nichole M. Cerutti, Jonathan P. Clark, Stuart C. Davidson, Keneth Davies, Martin J. Drysdale, Jeffrey Engelman, Anna Estevan-Barber, Andrea Gohlke, Christopher H. Gray, Daniel A. Guthy, Min Hong, Alana Hopkins, Luke D. Hutchinson, Jennifer Konczal, Michel Maira, Duncan McArthur -
New antibiotic for urinary tract infections nabs FDA approval Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-03-31
Discover the world’s best science and medicine | Nature.com
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Advances And Challenges in Immunosuppressive Antibody Drug Conjugates Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-03-31
Aiman A. Yaseen, L. Nathan Tumey -
Synthesis and identification of azocoumarin derivatives toward imaging of α-synuclein aggregates in the brain Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-03-29
Meiting Mao, Yu Zhou, Huihui Zhang, Pengxin Deng, Jie Yang, Jing Zhong, Na Li, Qiangqiang Liu, Xianghui Li, Xiaoai Wu, Yan Cheng -
Discovery of environment-sensitive fluorescent ligands for SHP2 imaging in living cells and tumor sections Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-03-31
Dong Liang, Chen Yu, Chuanhao Guo, Yan Lan, Shiyi Chen, Yu Zhang, Lupei Du, Deqing Sun, Minyong Li, Wei Zhao -
A new paradigm for immunotherapy in glioblastoma Nat. Med. (IF 58.7) Pub Date : 2025-03-31
Yosef Ellenbogen, Gelareh Zadeh -
The role of distress in female sexual dysfunction during menopause Nat. Med. (IF 58.7) Pub Date : 2025-03-31
Jiali Duan, John S. Ji, Rong Chen, Martha Hickey, Lan ZhuFemale sexual dysfunction (FSD) has historically received less attention than male sexual dysfunction, in terms of research, diagnosis and treatment, for various reasons, including culturally specific societal stigma, lack of awareness and diagnostic complexities. Sex-hormone insufficiency has long been considered a primary cause of FSD1, particularly during menopause. Menopause marks the end of reproductive
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A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease Nat. Med. (IF 58.7) Pub Date : 2025-03-31
Hamilton Se-Hwee Oh, Deniz Yagmur Urey, Linda Karlsson, Zeyu Zhu, Yuanyuan Shen, Amelia Farinas, Jigyasha Timsina, Michael R. Duggan, Jingsha Chen, Ian H. Guldner, Nader Morshed, Chengran Yang, Daniel Western, Muhammad Ali, Yann Le Guen, Alexandra Trelle, Sanna-Kaisa Herukka, Tuomas Rauramaa, Mikko Hiltunen, Anssi Lipponen, Antti J. Luikku, Kathleen L. Poston, Elizabeth Mormino, Anthony D. Wagner, -
Plasma MTBR-tau243 biomarker identifies tau tangle pathology in Alzheimer’s disease Nat. Med. (IF 58.7) Pub Date : 2025-03-31
Kanta Horie, Gemma Salvadó, Rama K. Koppisetti, Shorena Janelidze, Nicolas R. Barthélemy, Yingxin He, Chihiro Sato, Brian A. Gordon, Hong Jiang, Tammie L. S. Benzinger, Erik Stomrud, David M. Holtzman, Niklas Mattsson-Carlgren, John C. Morris, Sebastian Palmqvist, Rik Ossenkoppele, Suzanne E. Schindler, Oskar Hansson, Randall J. Bateman -
From Bones to Bugs: Structure-Based Development of Raloxifene-Derived Pathoblockers That Inhibit Pyocyanin Production in Pseudomonas aeruginosa J. Med. Chem. (IF 6.8) Pub Date : 2025-03-29
Marie Thiemann, Moritz Zimmermann, Christina Diederich, Huilin Zhan, Mikhail Lebedev, Jakob Pletz, Janosch Baumgarten, Maria Handke, Mathias Müsken, Rolf Breinbauer, Gabriela Krasteva-Christ, Esther Zanin, Martin Empting, Matthias Schiedel, Conrad Kunick, Wulf Blankenfeldt -
Systematic review and meta-analysis of intravenous iron therapy for patients with heart failure and iron deficiency Nat. Med. (IF 58.7) Pub Date : 2025-03-30
Stefan D. Anker, Mahir Karakas, Robert J. Mentz, Piotr Ponikowski, Javed Butler, Muhammad Shahzeb Khan, Khawaja M. Talha, Paul R. Kalra, Adrian F. Hernandez, Hillary Mulder, Frank W. Rockhold, Marius Placzek, Christian Röver, John G. F. Cleland, Tim FriedeUncertainty remains about the effect of intravenous (IV) iron on outcomes for heart failure (HF) with iron deficiency. Here, we summarize the efficacy and safety of IV iron from six trials (FAIR-HF, CONFIRM-HF, AFFIRM-AHF, IRONMAN, HEART-FID, and FAIR-HF2) including 7,175 patients. In comparison to prior analyses, this meta-analysis adds new data from FAIR-HF2, uses a harmonized and robust Bayesian
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Liberal fluid intake versus fluid restriction in chronic heart failure: a randomized clinical trial Nat. Med. (IF 58.7) Pub Date : 2025-03-30
Job J. Herrmann, Hans-Peter Brunner-La Rocca, Lisette E. H. J. M. Baltussen, Fabienne Beckers-Wesche, Sebastiaan C. A. M. Bekkers, Louise Bellersen, J. W. Martijn van Eck, H. Carlijne Hassing, Tiny Jaarsma, Gerard C. M. Linssen, Ron Pisters, Sandra Sanders-van Wijk, Marjolein H. I. Verdijk, M. Louis Handoko, Peter van der Meer, Frederik H. Verbrugge, James L. Januzzi, Antoni Bayés-Genís, Robby Nieuwlaat -
New Arylpiperazines as Potent and Selective Dopamine D4 Receptor Ligands Potentially Useful to Treat Glioblastoma J. Med. Chem. (IF 6.8) Pub Date : 2025-03-29
Federica Matteucci, Pegi Pavletić, Alessandro Bonifazi, Fabio Del Bello, Gianfabio Giorgioni, Alessandro Piergentili, Consuelo Amantini, Laura Zeppa, Emanuela Sabato, Giulio Vistoli, Rian Garland, Hideaki Yano, Monica Castagna, Valerio Mammoli, Loredana Cappellacci, Alessia Piergentili, Wilma Quaglia -
Design, Synthesis, Evaluation, and SAR of 5-Phenylisoindoline Derivatives, a Potent Class of Small-Molecule Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 (PD-1/PD-L1) Interaction J. Med. Chem. (IF 6.8) Pub Date : 2025-03-28
Tian Lu, Jiyi Zhang, Qiyu Chen, Mengyue Ni, Jingwen Zhang, Yufei Wu, Ruining Jia, Yuji Wang -
TCM theory-inspired discovery of DNJ-flavonoid conjugates as broad-spectrum anti-SARS-CoV-2 agents by primarily targeting ER-associated glycoprotein folding process Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-03-29
Yan-Yun Liu, Zheng-Ao Li, Yu-Zheng Zhou, Sen-Lin Wang, Zong-Peng Chen, Si-Xu Liu, Peng Zhan, Ying-Jun Zhou, Zan-Xian Xia, Xu Deng -
Exploiting structural variability in the kinase back-pocket to modulate polypharmacology of TAM inhibitors Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-03-28
Megan D. Hopkins, Dehui Zhang, Zhilong Chen, Andrew L. McIver, Justus M. Huelse, Jyoti P. Mahajan, Kaikai Lyu, Xiangbo Yang, Michael A. Stashko, Brittany Smith, Tsz Y. Yeung, H. Shelton Earp, Stephen V. Frye, Deborah DeRyckere, Dmitri Kireev, Douglas K. Graham, Xiaodong Wang -
Optimizing the Pharmacokinetics and Selectivity of TMPRSS2 Inhibitors Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-03-28
Sára Ferková, Matthieu Lepage, Antoine Désilets, Kevin Assouvie, Gabriel Lemieux, Isabelle Brochu, Ulrike Froehlich, Alice Gravel-Trudeau, Jules Vastra, François Jean, Philippe Sarret, Richard Leduc, Pierre-Luc Boudreault -
Discovery and Optimization of a Novel Carboxamide Scaffold with Selective Antimalarial Activity Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-03-28
Alicia Wagner, Roger Trombley, Maris Podgurski, Anthony A. Ruberto, Meng Cui, Caitlin A. Cooper, William E. Long, Gia-Bao Nguyen, Adriana A. Marin, Sarah Lee Mai, Franco Lombardo, Steven P. Maher, Dennis E. Kyle, Roman Manetsch -
Repurposing the amino-3,5-dicyanopyridine scaffold from adenosine receptor ligands to carbonic anhydrase activators Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-03-28
Erica Vigiani, Alessandro Bonardi, Daniela Catarzi, Flavia Varano, Sara Calenda, Costanza Ceni, Giulia Vagnoni, Andrea Angeli, Alessio Nocentini, Paola Gratteri, Claudiu T. Supuran, Vittoria Colotta -
Synthesis and structure-activity evaluation of a series of novel tricyclic STING activators Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-03-28
Sourav Basu, Sandip Middya, Ritesh Shrivastava, David C. Pryde, Rajib Ghosh, Dharmendra B. Yadav, Monali Banerjee, Arjun Surya -
2-(Phenylamino)-7,8-dihydroquinazolin-5(6H)-one, a promising scaffold for MAO-B inhibitors with potential GSK3β targeting Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-03-28
Maria Luisa Di Paolo, Silvia Salerno, Giulia Nordio, Francesco Piazzola, Stefania Sarno, Giuliana Sarno, Benito Natale, Valeria Poggetti, Antonella Borreca, Emma Baglini, Elisabetta Barresi, Federico Da Settimo, Sandro Cosconati, Sabrina Castellano, Sabrina Taliani, Lisa Dalla Via -
Design, synthesis and preliminary structure-activity relationship of 2-iminothiazolidine-4-one derivatives against Schistosoma japonicum in vitro and in vivo Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-03-24
Yinyin Li, Ling Deng, Xiaofeng Hua, Yumei Zhong, Peiyi Chen, Jiayi Shen, Lu Ouyang, Lvyin Zheng, Wei Guo -
Ecdysteroid-Containing Squalenoylated Self-Assembling Nanoparticles Exert Tumor-Selective Sensitization to Reactive Oxygen Species (ROS)-Induced Oxidative Damage While Protecting Normal Cells: Implications for Selective Radiotherapy J. Med. Chem. (IF 6.8) Pub Date : 2025-03-28
Máté Vágvölgyi, Endre Kocsis, Bizhar A. Tayeb, István Zupkó, Renáta Minorics, Ana Martins, Zsófia Hoyk, Gergő Ballai, Imre Szenti, Zoltán Kónya, Tamás Gáti, Dóra Bogdán, Gábor Tóth, Attila Hunyadi -
NIR-II aza-BODIPY Platform for the Development of a Fluorescent Antibody Drug Conjugate J. Med. Chem. (IF 6.8) Pub Date : 2025-03-28
Elisa Chazeau, Angélique Pipier, K. David Wegner, François Ghiringhelli, Lucie Sancey, Catherine Paul, Christine Goze -
Discovery of the 2,3-Dihydrobenzopyrane-4-one as a Potent FTO Inhibitor against Obesity-Related Metabolic Diseases J. Med. Chem. (IF 6.8) Pub Date : 2025-03-28
Duo Ma, Xianan Liu, Xingxing Zhang, Yaling Hong, Yumeng Wang, Famin Zhang, Leran Du, Junjie Zhao, Quan Wang, Cui Chang, Wenhu Liu, Yan Lou, Xinhua Liu -
The Sprint to Develop Coronavirus Antivirals J. Med. Chem. (IF 6.8) Pub Date : 2025-03-28
Michael F. T. KoehlerThe preclinical work leading to the discovery of PF-07321332 (nirmatrelvir) is described in the Featured Article summarized in this Viewpoint. This work resulted in an Emergency Use Authorization (EUA) for Paxlovid within two years of the project’s start. In addition to the medicinal chemistry approach taken, the authors describe how they achieved this remarkable speed.
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Development of Diphenyl-1,2,4-Oxadiazole Analogues as Allosteric Modulators of the RXFP3 Receptor: Evaluation of Importance of the N-Substituted-2-Pyrrolidone Moiety in RLX-33 J. Med. Chem. (IF 6.8) Pub Date : 2025-03-27
Dongliang Guan, Hetti Handi Chaminda Lakmal, Brooke N. Bender, Md Toufiqur Rahman, Elaine A. Gay, Daniel G. Barrus, Alejandro M. Mosera, Andrew T. Kerr, Joyce Besheer, Chunyang Jin -
Non-incretin peptide curbs appetite Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-03-28
Discover the world’s best science and medicine | Nature.com
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Discovery of Novel Tetrahydroquinoline Derivatives as Potent, Selective, and Orally Available AR Antagonists Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-03-28
Leer Yuan, Jianing Liao, Yiyang Qin, Lvtao Cai, Minkui Zhang, Jinbiao Liao, Dan Li, Tingjun Hou, Rong Sheng -
Heterocycle-fused phenylcyclohexylamines as novel multi-target antagonists of N-methyl-d-aspartate (NMDA) receptor and monoamine transporter for treating depression Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-03-27
Fuqiang Zheng, Zhengtao Hu, Hai Chen, Jiaxin Cheng, Qiongqiong Hou, Jiefang Zheng, Xudong Gong, Jing Ji, Nuriddinov Zayniddin, Safomuddin Abduahadi, Obul Mamateli, Guan Wang, Pengcheng Li, Tianwen Hu, Guanghui Tian, Zhijian Xu, Weiliang Zhu, Haji Akber Aisa, Jingshan Shen, Yang He -
CUPID: a free drug discovery platform for the explainable multi-ion channel assessment of cardiotoxicity Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-03-27
Nicola Gambacorta, Fabrizio Mastrolorito, Maria Vittoria Togo, Vincenzo Amenduni, Marco Mele, Antonella Liantonio, Antonietta Mele, Annamaria De Luca, Cosimo Damiano Altomare, Valentina Belgiovine, Anna Rita Tondo, Francesca Cutropia, Lydia Siragusa, Nicola Amoroso, Fulvio Ciriaco, Paola Imbrici, Daniela Trisciuzzi, Orazio Nicolotti -
O-Derivatization of Natural Tropolone and β-Thujaplicin Leading to effective Inhibitors of Human Carbonic Anhydrases IX and XII Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-03-27
Francesco Melfi, Ilaria D’Agostino, Simone Carradori, Fabrizio Carta, Andrea Angeli, Giosuè Costa, Gioele Renzi, Ana Čikoš, Daniela Vullo, Josip Rešetar, Marta Ferraroni, Chiara Baroni, Francesca Mancuso, Rosaria Gitto, Francesca Alessandra Ambrosio, Emanuela Marchese, Roberta Torcasio, Nicola Amodio, Clemente Capasso, Stefano Alcaro, Claudiu T. Supuran -
Discovery of phenylisoxazolidine analogs targeting receptor interacting protein kinase 1 with anti-inflammatory activity Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-03-23
Liangliang Ma, Yonglei Zhang, Zhongwen Luo, Long Zheng, Yuhan Jiang, Meiting Zou, Yiwei Zheng, Lingyi Kong, Xiaobing Wang -
Structural optimization and discovery of high effective isopropanolamine-based TPS1 inhibitors as promising broad-spectrum fungicide candidates Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-03-24
Zhiyang Jiang, Na Wang, Jinxiu Chen, Huan Xu, Wenya Zhu, Dongmei Shi, Chen Qian, Jie Shi, Xinyue Hu, Zhijian Xu, Dongli Wang, Xinling Yang, Junfeng Liu, Hongxia Duan -
Fungal dimeric xanthones as anticancer agents by novelly stimulating sodium-calcium exchanger 1 Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-03-27
Guolong Zhou, Kemin Dong, Xiaoyuan Xu, Ruihong Guo, Gang Li, Jianxin Wang, Liyong Zhou, Shuangzhi Yuan, Hongxiang Lou, Hongmei Li, Hui Dong, Xiaoping Peng -
Author Correction: A multi-modal single-cell and spatial expression map of metastatic breast cancer biopsies across clinicopathological features Nat. Med. (IF 58.7) Pub Date : 2025-03-28
Johanna Klughammer, Daniel L. Abravanel, Åsa Segerstolpe, Timothy R. Blosser, Yury Goltsev, Yi Cui, Daniel R. Goodwin, Anubhav Sinha, Orr Ashenberg, Michal Slyper, Sébastien Vigneau, Judit Jané‐Valbuena, Shahar Alon, Chiara Caraccio, Judy Chen, Ofir Cohen, Nicole Cullen, Laura K. DelloStritto, Danielle Dionne, Janet Files, Allison Frangieh, Karla Helvie, Melissa E. Hughes, Stephanie Inga, Abhay KanodiaCorrection to: Nature Medicine https://doi.org/10.1038/s41591-024-03215-z, published online 30 October 2024.
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Targeting GDF-15 in cancer cachexia and immunity Nat. Med. (IF 58.7) Pub Date : 2025-03-28
Louise Y. Cheng, Jayesh Desai, Paul J. Neeson -
Author Correction: Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer’s disease Nat. Med. (IF 58.7) Pub Date : 2025-03-28
Lynn van Olst, Brooke Simonton, Alex J. Edwards, Anne V. Forsyth, Jake Boles, Pouya Jamshidi, Thomas Watson, Nate Shepard, Talia Krainc, Benney MR Argue, Ziyang Zhang, Joshua Kuruvilla, Lily Camp, Mengwei Li, Hang Xu, Jeanette L. Norman, Joshua Cahan, Robert Vassar, Jinmiao Chen, Rudolph J. Castellani, James AR Nicoll, Delphine Boche, David GateCorrection to: Nature Medicine https://doi.org/10.1038/s41591-025-03574-1, published online 6 March 2025.
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The health consequences of foreign policy sanctions Nat. Med. (IF 58.7) Pub Date : 2025-03-28
Foreign aid sanctions reverse progress on child and maternal health and increase mortality rates, according to an analysis of three decades’ worth of data from 113 countries.
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Links between climate change and suicidal behavior risks Nat. Med. (IF 58.7) Pub Date : 2025-03-28
Francis Vergunst, Massimiliano Orri, Alberto Forte, Marie-Claude Geoffroy -
Potent and Selective Human Constitutive Androstane Receptor Activator DL5055 Facilitates Cyclophosphamide-Based Chemotherapies J. Med. Chem. (IF 6.8) Pub Date : 2025-03-27
Dongdong Liang, Linhao Li, Yong Ai, Zhihui Li, William D. Hedrich, Srilatha Sakamuru, Caitlin Lynch, Wenbo Yu, Ismael Watts-Ouattara, Scott Heyward, Menghang Xia, Alexander D. MacKerell, Jr., Hongbing Wang, Fengtian Xue -
Discovery of Highly Potent AKR1C3 Inhibitors Treating Sorafenib-Resistant Hepatocellular Carcinoma J. Med. Chem. (IF 6.8) Pub Date : 2025-03-27
Shuaishuai Xing, Jiheng Jiang, Xianglin Chu, Xiaolong Wang, Zhiqiang Wang, Xinyu Li, Bingbing Lv, Can Guo, Siyu He, Leyan Wang, Chenyu Zhang, Qinglong Guo, Li Zhao, Pengfei Fang, Feng Feng, Haopeng Sun -
Discovery of AMG 193, an MTA-Cooperative PRMT5 Inhibitor for the Treatment of MTAP-Deleted Cancers J. Med. Chem. (IF 6.8) Pub Date : 2025-03-27
Liping H. Pettus, Matthew Bourbeau, Nuria A. Tamayo, Albert Amegadzie, Diane Beylkin, Shon K. Booker, John Butler, Michael J. Frohn, Matthew R. Kaller, Todd Kohn, Brian A. Lanman, Kexue Li, Qingyian Liu, Vu Ma, Jose Medina, Ana E. Minatti, Patricia Lopez, Francesco Manoni, Alex Pickrell, Nicholas Weires, Jan Andersson, Sanne Cowland, Sanne Glad, Ian Sarvary, Mikkel Vestergaard, Weikun Li, Sudipa Ghimire-Rijal -
Application of Machine Learning and Mechanistic Modeling to Predict Intravenous Pharmacokinetic Profiles in Humans J. Med. Chem. (IF 6.8) Pub Date : 2025-03-27
Xuelian Jia, Donato Teutonico, Saroj Dhakal, Yorgos M. Psarellis, Alexandra Abos, Hao Zhu, Panteleimon D. Mavroudis, Nikhil Pillai -
Towards P2X4 Positron Emission Tomography Tracing J. Med. Chem. (IF 6.8) Pub Date : 2025-03-27
Stephanie Federico -
Discovery of novel 1,2,3-Triazole hybrids derivatives as vasorelaxant agents: Molecular structure, Hirshfield surface, in-vivo and in-silico investigation by molecular docking simulation Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-03-27
Yassine Rhazi, Ismail Bouadid, Asmae Nakkabi, Usama Raza, Lohith Tumakuru Nagarajappa, Noemi Deak, Albert Soran, Mohamed El Yazidi, Marwa Alaqarbeh, Abdessamad Tounsi, Mohamed Anouar Harrad, Mohamed Eddouks -
Recent advances in medicinal chemistry strategies for the development of METTL3 inhibitors Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-03-22
Gengwu Li, Wei Chen, Dan Liu, Shibing Tang -
Tetracationic tetraaryltetranaphtho[2,3]porphyrins for photodynamic inactivation against Staphylococcus aureus biofilm Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-03-22
Le Mi, Tao Xu, Ying-Yuan Peng, Marina G. Strakhovskaya, Yi-Jing Zhang, Gennady A. Meerovich, Tebello Nyokong, Yi-Jia Yan, Zhi-Long Chen -
Discovery of ultra short β-peptoids with selective activity against drug-resistant Mycobacterium tuberculosis Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-03-26
John Kauffman, Jake Cuevas, Janaya Feiner, Margaret Metzger, Gauri Shetye, Baojie Wan, Mallique Qader, Duc Nguyen, Angela Nugent, Akil Hossain, Scott Franzblau, Francis E. Umesiri -
Exploring Si-phthalocyanines with different valency for PSMA-targeted photodynamic therapy: Synthesis and preclinical validation Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-03-24
Valentina Dinatale, Martina Capozza, Rachele Stefania, Simona Liuzzi, Henriette S. de Bruijn, Roisin McMorrow, Giorgia Zambito, Dominic Robinson, Laura Mezzanotte, Enzo Terreno -
A highly active angiotensin I-converting enzyme inhibitory peptide KAKW designed based on the role of C-terminal residue, and its antihypertensive effects on spontaneously hypertensive rats Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-03-24
Yangting Hu, Dewei Xie, Xujun Chen, Peng Li, Li Zhao, Bei Gao, Lei Du, Jingli Xie -
Design, synthesis, and antitumor activity of stapled peptide inhibitors targeting the RAS–RAF interactions Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-03-24
Dan Han, Zhou Yu, Kai Zhang, Conghao Gai, Peichao Zhang, Xiaoyun Chai, Xiaobing Zhuo, Qingjie Zhao, Yan Zou, Lie Zhu -
Synthesis of Benzo[h]quinoline derivatives and evaluation of their insecticidal activity against Culex pipiens L. larvae Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-03-24
Eman A.E. El-Helw, Wael S.I. Abou-Elmagd, Eslam M. Hosni, Mahmoud Kamal, Ahmed I. Hashem, Sayed K. Ramadan -
The silent battle to address the health crisis of conflict-induced air pollution Nat. Med. (IF 58.7) Pub Date : 2025-03-27
Karen J. Cloete, Goran Bandov, Samer AbuzerrConflict zones are plagued by air pollution from warfare-related activities, which exacerbates public health challenges, especially for vulnerable populations and the environments they live in.
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Author Correction: Disruption of neural periodicity predicts clinical response after deep brain stimulation for obsessive-compulsive disorder Nat. Med. (IF 58.7) Pub Date : 2025-03-26
Nicole R. Provenza, Sandesh Reddy, Anthony K. Allam, Sameer V. Rajesh, Nabeel Diab, Gabriel Reyes, Rose M. Caston, Kalman A. Katlowitz, Ajay D. Gandhi, Raphael A. Bechtold, Huy Q. Dang, Ricardo A. Najera, Nisha Giridharan, Katherine E. Kabotyanski, Faiza Momin, Mohammed Hasen, Garrett P. Banks, Brian J. Mickey, Brent M. Kious, Ben Shofty, Benjamin Y. Hayden, Jeffrey A. Herron, Eric A. Storch, AnkitCorrection to: Nature Medicine https://doi.org/10.1038/s41591-024-03125-0, published online 12 July 2024.
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Author Correction: First-line cadonilimab plus chemotherapy in HER2-negative advanced gastric or gastroesophageal junction adenocarcinoma: a randomized, double-blind, phase 3 trial Nat. Med. (IF 58.7) Pub Date : 2025-03-26
Lin Shen, Yanqiao Zhang, Ziyu Li, Xiaotian Zhang, Xiangyu Gao, Bo Liu, Yusheng Wang, Yi Ba, Ning Li, Ruixing Zhang, Jingdong Zhang, Ye Chen, Jian Chen, Mingzhu Huang, Yang Fu, Mulin Liu, Zheng Liu, Jun Zhao, Wei Li, Jia Wei, Changzheng Li, Nong Xu, Zengqing Guo, Bangwei Cao, Lian Liu, Peng Nie, Lixin Wan, Lili Sheng, Zhenyang Liu, Yifu He, Kangsheng Gu, Guowu Wu, Weibo Wang, Futong Zhang, WenshengCorrection to: Nature Medicine https://doi.org/10.1038/s41591-024-03450-4, published online 22 January 2025.
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Rwanda’s science-led response to Marburg virus holds lessons for other outbreaks in Africa Nat. Med. (IF 58.7) Pub Date : 2025-03-26
Faraan O. Rahim, Mosoka Fallah, Claude Mambo Muvunyi, Loko Abraham, Sabin Nsanzimana, Jean KaseyaOn 27 September 2024, Rwanda triggered international alarms when the country announced its first confirmed case of Marburg virus disease (MVD), a severe hemorrhagic fever similar to Ebola, with a case fatality rate as high as 88%. By 3 October, the number of confirmed cases had risen to 36, with over 70% occurring among healthcare workers, and 11 fatalities reported across 7 of Rwanda’s 30 districts
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Pharma companies collaborate on secure data sharing for AI Nat. Med. (IF 58.7) Pub Date : 2025-03-26
Using a novel federated learning approach, organizations can pool resources to develop better drug-discovery AI models — without sharing any private data.
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A global call to action for disability inclusion in health research Nat. Med. (IF 58.7) Pub Date : 2025-03-26
Anna M. Anderson, Rachelle A. Martin, Willyanne DeCormier Plosky, Lieketseng Ned, Bonnielin K. Swenor, Jodie Bailie, Kaaren Mathias, Jasjot K. Maggo, Mildred A. Omino, Amy M. Russell, Anna M. M. Lawson, Anna E. Brown, Barbara E. Bierer, Sameed Shariq, Mrisho Mwifadhi, Katherine H. O. Deane, Sharad Philip, Victoria Shepherd, Nicola E. Walsh, Gretl A. McHugh
更新日期：2025-03-31
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