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Minimalist Natural ORPphilin Macarangin B Delineates OSBP Biological Function J. Med. Chem. (IF 6.8) Pub Date : 2024-12-20 Gwenaëlle Jézéquel, Zoé Grimanelli, Carole Guimard, Joëlle Bigay, Juliano Haddad, Jérôme Bignon, Cécile Apel, Vincent Steinmetz, Laurie Askenatzis, Hélène Levaïque, Clara Pradelli, Van Cuong Pham, Doan T. M. Huong, Marc Litaudon, Romain Gautier, Chaker El Kalamouni, Bruno Antonny, Sandy Desrat, Bruno Mesmin, Fanny Roussi
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MoA Studies of the TEAD P-Site Binding Ligand MSC-4106 and Its Optimization to TEAD1-Selective Amide M3686 J. Med. Chem. (IF 6.8) Pub Date : 2024-12-20 Timo Heinrich, Daniel Schwarz, Carl Petersson, Jakub Gunera, Sakshi Garg, Richard Schneider, Marina Keil, Lisa Grimmeisen, Andrea Unzue Lopez, Lisa Albers, Sarah Schlesiger, Alessia Gambardella, Joerg Bomke, Emma Carswell, Heike Schilke, Patrizia Diehl, Benjamin Doerfel, Djordje Musil, Elisabeth Trivier, Rebecca Broome, Sam Marshall, Alexander Balsiger, Erik Friedrich, Ana R. Lemos, Sandra P. Santos
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Identification of Novel Organo-Se BTSA-Based Derivatives as Potent, Reversible, and Selective PPARγ Covalent Modulators for Antidiabetic Drug Discovery J. Med. Chem. (IF 6.8) Pub Date : 2024-12-20 Fangyuan Chen, Qingmei Liu, Lei Ma, Cuishi Yan, Haiman Zhang, Zhi Zhou, Wei Yi
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Identification of Novel Human 15-Lipoxygenase-2 (h15-LOX-2) Inhibitors Using a Virtual Screening Approach J. Med. Chem. (IF 6.8) Pub Date : 2024-12-19 Lucas G. Viviani, Thais S. Iijima, Erika Piccirillo, Leandro Rezende, Thiago G. P. Alegria, Luis Eduardo S. Netto, Antonia T.-do Amaral, Sayuri Miyamoto
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New Series of 3-Pyridyl-1,3-Thiazoles: In Vitro and In Vivo Anti-Trypanosomatidae Profile, in vitro and in silico Mechanism of Action approach Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-20 Vanessa Gouveia de Melo Silva, Lucas Manoel da Silva Sousa, Expedito Lopes Fernandes Junior, Graziella Leite Brondani, Isabeli Maria de Albuquerque Oliveira, Danilo Cesar Galindo Bedor, Isabella Barbosa Pereira Lopes, Fabio André Brayner, Luiz Carlos Alves, Marton Kaique de Andrade Cavalcante, Daniele Santana de Souza Oliveira, Maria Carolina Accioly Brelaz-de-Castro, Policarpo Ademar Sales Junior
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Benzimidazole analogues active against adult Schistosoma mansoni: SAR analyses, In vivo efficacy in mice, and preliminary mechanistic studies as potential inhibitors of hemozoin formation Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-19 Godwin A. Dziwornu, Henrietta Dede Attram, Cécile Haberli, Keabetswe Masike, Mathew Njoroge, Jennifer Keiser
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Discovery and optimization of 1,2,4-triazole derivatives as novel ferroptosis inhibitors Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-19 Jiawei Zhang, Fang Lin, Yijie Xiao, Si-Yu Cen, Bi-Wen Wan, Xuan Li, Yahui Zhao, Yi He, Hai-Xin Yuan, Shenyou Nie
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Synthetic Approaches and Clinical Applications of Representative HDAC Inhibitors for Cancer Therapy: A Review Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-19 Zhengming Lv, Tianyi Ji, Jie Liu, Xu Sun, Huimin Liang
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Synthesis and Clinical Application of New Drugs Approved by NMPA in 2023 Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-19 Lijuan Xie, Yingying Wang, Kunyu Wang, Wanying Chen, Fuwei Yang
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Advances in Selective c-MET Kinase Inhibitors: Application of Fused [5,6]-Bicyclic Nitrogen-Containing Cores for Anticancer Drug Design Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-19 Mehdi Valipour, Zahra Zakeri khatir, Adileh Ayati, Asieh Hosseini, Mohammad Sheibani, Hamid Irannejad
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From Challenges to Solutions: A Review of Fourth-Generation EGFR Tyrosine Kinase Inhibitors to Overcome the C797S Triple Mutation in Non-Small Cell Lung Cancer Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-19 Iqrar Ahmad, Harun M. Patel
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Discovery of SET domain-binding primary alkylamine-tethered degraders for the simultaneous degradation of NSD2-long and RE-IIBP isoforms Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-17 Linghao Hu, Hesong Xu, Ye Xu, Haowen Chen, Hanrui Jiang, Dounan Xu, Huimin Zhang, Cheng Luo, Shijie Chen, Mingliang Wang
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Clinically approved representative small-molecule drugs for cardiopathy therapy Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-16 Shaowei Ma, Min Jiang, Xiao Wang, Bin Li
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Discovery and biological evaluation of potent 2-trifluoromethyl acrylamide warhead-containing inhibitors of protein disulfide isomerase Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-16 Jung-Chun Chu, Keng-Chang Tsai, Ting-Yu Wang, Tzu-Yin Chen, Ju-Ying Tsai, Tien Lee, Mei-Hsiang Lin, Yves S.Y. Hsieh, Chin-Chung Wu, Wei-Jan Huang
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Discovery of novel XPO1 PROTAC degraders for the treatment of acute myeloid leukemia Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-17 Guangyong Chen, Zhuo Chen, Huimin Liu, Chen Meng, Kai Wang, Haibin Lu, Fuwei Yang
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Dihydrofolate reductase inhibitory potential of 1H-indole-based-meldrum linked 1H-1,2,3-triazoles as new anticancer derivatives: In-vitro and in-silico studies Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-15 Satya Kumar Avula, Saeed Ullah, Amirhossein Ebrahimi, Ali Rostami, Sobia Ahsan Halim, Ajmal Khan, Muhammad U. Anwar, Simon Gibbons, René Csuk, Ahmed Al-Harrasi
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Fluorinated Coumarin Derivatives as Selective PET Tracer for MAO-B Imaging J. Med. Chem. (IF 6.8) Pub Date : 2024-12-19 Nan Wu, Xiaojun Zhang, Yuying Li, Jinming Zhang, Mengchao Cui
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Design, Synthesis, and Biological Evaluation of 2-Arylaminopyrimidine Derivatives as Dual Cathepsin L and JAK Inhibitors for the Treatment of Acute Lung Injury J. Med. Chem. (IF 6.8) Pub Date : 2024-12-19 Chunwei Shen, Zhengtong Mao, Tianpeng Chen, Yingying Wei, Tao Zhou, Ningyuan Zhong, Gaoyang Zhu, Qiwen Shi, Zheyu Xie, Huajun Zhao, Xingxian Zhang
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Identification of an Isoxazole Derivative as an Antitubercular Compound for Targeting the FadD Enzymes of Mycobacterium tuberculosis J. Med. Chem. (IF 6.8) Pub Date : 2024-12-18 Nidhi Rani, Raju S. Rajmani, Avadhesha Surolia
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Eradication of Therapy-Resistant Cancer Stem Cells by Novel Telmisartan Derivatives J. Med. Chem. (IF 6.8) Pub Date : 2024-12-18 Anna M. Schoepf, Maximilian Gebhart, Martin Federspiel, Isabel Heidegger, Martin Puhr, Madlen Hotze, Marcel Kwiatkowski, Andreas Pircher, Dominik Wolf, Sieghart Sopper, Ronald Gust, Stefan Salcher
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Structurally diverse chromane meroterpenoids from Rhododendron capitatum with multifunctional neuroprotective effects Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-18 Ye-Fan Shi, Yue-Tong Zhu, Zi-Han Zhang, Meng-Song Chen, Song Gao, Qiang Zhang, Chun-Huan Li
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Novel Steroidal β-Carboline Derivatives as Promising Antibacterial Candidates against Methicillin-Resistant Staphylococcus aureus Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-18 Haibo Huo, Wenjia Dan, Libo Qin, Jiaxue Bo, Xiaonan Zhang, Chaofu Yang, Bianxia Bai, Jiahong Ren, Baojun Shi, Jian Li
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Unravelling the potential of natural chelating agents in the control of Staphylococcus aureus and Pseudomonas aeruginosa biofilms Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-15 Miguel M. Leitão, Ariana S.C. Gonçalves, Joana Moreira, Carlos Fernandes, Fernanda Borges, Manuel Simões, Anabela Borges
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Discovery of pyridine-based derivatives as FLT3 inhibitors for the treatment of acute myeloid leukemia Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-16 Beijing Chen, Zhongyuan Wang, Qi Chen, Ying Zhang, Shengfei Wu, Yu Zhang, Aihong Li, Weiwei Ouyang, Lijie Sima, Xiaoxu Li, Dongsheng Zhao, Bilan Luo, Jianta Wang, Lei Tang, Xiaoming Su, Weike Liao
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Design, synthesis and biological evaluation of new H2S-releasing rivastigmine derivatives as neuroprotective molecules Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-17 Simona Sestito, Italo Cirone, Simona Sagona, Massimiliano Runfola, Lorenzo Raffellini, Veronica La Rocca, Valentina Citi, Alma Martelli, Simona Daniele, Michele Lai, Vincenzo Calderone, Claudia Martini, Clementina Manera, Simona Rapposelli
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Hypoxia Activated Nitric Oxide Donor Compounds for the Prevention and Treatment of Myocardial Hypoxia-Induced Injury J. Med. Chem. (IF 6.8) Pub Date : 2024-12-18 Wanxiang Yang, Wen Zhou, Shaohua Gou
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Impact of Linker Composition on VHL PROTAC Cell Permeability J. Med. Chem. (IF 6.8) Pub Date : 2024-12-18 Yordanos Esubalew Abeje, Lianne H. E. Wieske, Vasanthanathan Poongavanam, Stefanie Maassen, Yoseph Atilaw, Philipp Cromm, Lutz Lehmann, Mate Erdelyi, Daniel Meibom, Jan Kihlberg
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Orvinol-based opioid receptor antagonist fluorinated at C(20)-pharmacophore Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-18 A.A. Ambartsumyan, I.V. Belozertseva, O.А. Dravolina, E.E. Zvartau, I.V. Sandulenko, M.V. Zelentsova, A.S. Peregudov, S.K. Moiseev
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Synthesis and structural modification of the natural product Ivesinol to discover novel autophagy activators Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-17 Zhi-Peng Wang, Wenxin You, Jie Peng, Biao Xu, Xiaohong Yang, Wanyan Tang, Yun He, Aimin Yang, Chao Yu, Weiqi Nian
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Correction of aberrant splicing of ELP1 pre-mRNA by kinetin derivatives – a structure activity relationship study Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-17 Barbara Maková, Václav Mik, Barbora Lišková, Lenka Drašarová, Martina Medvedíková, Alena Hořínková, Petr Vojta, Marek Zatloukal, Lucie Plíhalová, Martin Hönig, Karel Doležal, Kristýna Forejt, Tomáš Oždian, Marián Hajdúch, Miroslav Strnad, Jiří Voller
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The potential of MAO inhibitors as chemotherapeutics in cancer: A literature survey Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-15 Sabina Sblano, Angelina Boccarelli, Caterina Deruvo, Gabriella La Spada, Modesto de Candia, Rosa Purgatorio, Cosimo Damiano Altomare, Marco Catto
Drug resistance in cancer is determined by genetic mutations and adaptations of tumor cells to drug treatments, raising a challenge in the treatment of cancer. Factors such as prolonged drug exposure, genetic variability among patients, and tumor heterogeneity have been established as contributors to rising incidence of drug resistance, prompting ongoing research into alternative therapies and combination
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FDA approves first HER2 × HER3 bispecific antibody Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-12-18
Discover the world’s best science and medicine | Nature.com
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Pairing up with GLP-1 to combat obesity Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-12-18
Discover the world’s best science and medicine | Nature.com
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Open Targets: 10 years of partnership in target discovery Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-12-17 David G. Hulcoop, Gosia Trynka, Ellen M. McDonagh
The Open Targets consortium was founded in 2014 to translate insights from genetics and functional genomics into identifying and prioritizing therapeutic targets. We highlight key achievements and insights stemming from this partnership of academic and industry scientists.
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Discovery of N-Trifluoromethylated Noscapines as Novel and Potent Agents for the Treatment of Glioblastoma J. Med. Chem. (IF 6.8) Pub Date : 2024-12-17 Guangwei Cui, Yuhang Fan, Yue Yang, Yiwen Ma, Haiyang Deng, Pan Wang, Yuxin Zhu, Jian Li, Jinlian Wei, Yongqiang Zhang
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Modulating the Potency of BRD4 PROTACs at the Systems Level with Amine-Acid Coupling Reactions J. Med. Chem. (IF 6.8) Pub Date : 2024-12-17 Andrew McGrath, Haiyan Huang, Jean-Francois Brazeau, Zirong Zhang, Christopher O. Audu, Nadeem A. Vellore, Lu Zhu, Zhicai Shi, Jennifer D. Venable, Christine F. Gelin, Tim Cernak
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Pivotal Role of the Intracellular Microenvironment in the High Photodynamic Activity of Cationic Phthalocyanines J. Med. Chem. (IF 6.8) Pub Date : 2024-12-17 Dmitry A. Bunin, Roman A. Akasov, Alexander G. Martynov, Maria P. Stepanova, Svetlana V. Monich, Aslan Yu. Tsivadze, Yulia G. Gorbunova
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Guardians at the Gate: Optimization of Small Molecule Entry Inhibitors of Ebola and Marburg Viruses J. Med. Chem. (IF 6.8) Pub Date : 2024-12-16 Malaika D. Argade, Jazmin Galván Achi, Ryan Bott, Kimberly M. Morsheimer, Callum D. Owen, Christian A. Zielinski, Arsen M. Gaisin, Mario Alvarez, Terry W. Moore, Fan Bu, Fang Li, Michael Cameron, Manu Anantpadma, Robert A. Davey, Norton P. Peet, Lijun Rong, Irina N. Gaisina
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Structure-Based Development of Novel Spiro-Piperidine ASH1L Inhibitors J. Med. Chem. (IF 6.8) Pub Date : 2024-12-16 Guang Huang, Rhiannon Stevens, Devon G. Hucek, Trupta Purohit, Shuangjiang Li, Hongzhi Miao, Elise Trost, Geoff Hewett, Bradley Clegg, Se Ra Park, Krishani Rajanayake, Bo Wen, Duxin Sun, Tomasz Cierpicki, Jolanta Grembecka
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Recent Advances of Metal Complexes in the Treatment of Hepatocellular Carcinoma J. Med. Chem. (IF 6.8) Pub Date : 2024-12-16 Zhongren Xu, Yu Liu, Jiaqi Yang, Fuwei Li, Wukun Liu
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Combinatorial Synthesis toward the Discovery of Highly Cytotoxic Fe(III) Complexes J. Med. Chem. (IF 6.8) Pub Date : 2024-12-16 Felix Niemeier, Lisa-Marie Servos, Zisis Papadopoulos, Nicolás Montesdeoca, Kaixin Ni, Sascha Heinrich, Johannes Karges
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Precise Carrier-Free Pt(IV)-Nanobombs for Apoptosis/Ferroptosis Synergistic Tumor Therapy: A New Effective Method to Obtain Good Chemotherapy and Low Toxicity J. Med. Chem. (IF 6.8) Pub Date : 2024-12-16 Xu Guo, Xue-Jiao Liang, Jia-Le Liu, Zhi-Hui Li, Zhihao You, Dandan Zhao, Yali Song, Longfei Li, Xue-Qing Song
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Discovery of N-Phenyl-5-propyl-1H-pyrazole-3-carboxamide, with Selective Inhibition and Degradation of HDAC6 for the Treatment of Acute Liver Injury J. Med. Chem. (IF 6.8) Pub Date : 2024-12-16 Hao Cui, Guodong Zhang, Liyuan Zhang, Shilong Sun, Kang Yang, Aixin Gen, Penfeng Wang, Hui Wang, Qing-Qing Zhou, Hongmei Li, Yadong Chen, Yuqin Yao, Tao Lu, Lei Zhang, Yong Zhu
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Evaluation of Dynamic Light Scattering as an Effective Quality Control Method for Aggregates in Radiolabeled Antibodies J. Med. Chem. (IF 6.8) Pub Date : 2024-12-16 Huu Bao Nguyen, Hyun Park, Jeong Eun Lim, Thuy Tien Nguyen, Hwan Hui Kim, Kyeongwon Kim, Jung Young Kim, Kyo Chul Lee, Jeongsoo Yoo
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Antibody-Vincristine Conjugates as Potent Anticancer Therapeutic Agents J. Med. Chem. (IF 6.8) Pub Date : 2024-12-16 Agathe Boos, Julien Most, Héloïse Cahuzac, Louis Moreira da Silva, François Daubeuf, Stéphane Erb, Sarah Cianférani, Oscar Hernandez-Alba, Constantin Semenchenko, Igor Dovgan, Sergii Kolodych, Alexandre Detappe, Françoise Dantzer, Alain Wagner, Maria Zeniou, Guilhem Chaubet
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Design, Synthesis, and Biochemical Evaluation of Novel MLK3 Inhibitors: A Target Hopping Example J. Med. Chem. (IF 6.8) Pub Date : 2024-12-16 Pascal Sander, Martin P. Schwalm, Andreas Krämer, Lewis Elson, Alexander Rasch, Benedikt Masberg, Roland Selig, Adrian Sievers-Engler, Michael Lämmerhofer, Susanne Müller, Stefan Knapp, Wolfgang Albrecht, Stefan A. Laufer
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Corrigendum to “Design, synthesis, and evaluation of novel pleuromutilin aryl acrylate derivatives as promising broad-spectrum antibiotics especially for combatting multi-drug resistant gram-negative bacteria” [Eur. J. Med. Chem. 259 (2023) 115653] Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-17 Min Li, Jialin Li, Jingyi Li, Jie Zhang, Yuqing Zhao, Wenying Li, Yunfei Zhang, Jinrong Hu, Xiaolin Xie, Dezhu Zhang, Han Li, Qianqian Zhao, Hong Gao, Chengyuan Liang
The authors regret that “Fig. 13. Observation of main organ tissue sections of mice with systemic infection of MRSA treated with different doses of 5g and valnemulin, the scale bar represents 100 μm.” was incorrect in the original manuscript. The figure has now been updated with the correct version. This error occurred during the image assembly process but does not affect the experimental results,
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A novel cyanine photosensitizer for sequential dual-site GSH depletion and ROS-potentiated cancer photodynamic therapy Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-12 Li Chen, Jun Yang, Feijing Su, Zihang Liu, Shuai Huang, Jifa Zhang, Jinqi Li, Wuyu Mao
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Chemical engineering of CRISPR–Cas systems for therapeutic application Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-12-17 Halle M. Barber, Adrian A. Pater, Keith T. Gagnon, Masad J. Damha, Daniel O’Reilly
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Harnessing the biology of regulatory T cells to treat disease Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-12-16 Christine M. Wardell, Dominic A. Boardman, Megan K. Levings
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IRDiRC perspectives on the application of digital biomarkers in therapeutic development for rare diseases Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-12-16 Rajesh Krishna, Anneliene H. Jonker, Thomas Morel, Ken Sakushima, Anna M. G. Pasmooij, Daniel O’Connor
New approaches are needed to streamline clinical trials of drugs for patients with rare diseases. Digital biomarkers offer one such approach, but several challenges must be addressed to realize their potential.
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Discovery of the First Examples of Right Open Reading Frame Kinase 2 (RIOK2) Molecular Glue Degraders Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-15 Haowen Ma, Cong Liu, Zihao Li, Qiuchun Yu, Huilan Xiong, Chaomin Huang, Li Tan, Min Zhan, Zhang Zhang, Qian Cai
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Genomic and transmission dynamics of the 2024 Marburg Virus Outbreak in Rwanda Nat. Med. (IF 58.7) Pub Date : 2024-12-16 Yvan Butera, Leon Mutesa, Edyth Parker, Raissa Muvunyi, Esperance Umumararungu, Alisen Ayitewala, Jean Pierre Musabyimana, Alhaji Olono, Placide Sesonga, Olusola Ogunsanya, Emmanuel Kabalisa, Oluwatobi Adedokun, Nelson Gahima, Laetitia Irankunda, Chantal Mutezemariya, Richard Niyonkuru, Arlene Uwituze, Ithiel Uwizera, James Kagame, Arlette Umugwaneza, John Rwabuhihi, Fidele Umwanankabandi, Valens Mbonitegeka
The ongoing outbreak of Marburg virus disease (MVD) in Rwanda marks the third largest historically, though it has exhibited the lowest fatality rate. Genomic analysis of samples from 18 cases identified a lineage with limited internal diversity, closely related to a 2014 Ugandan case. Our findings suggest that the Rwandan lineage diverged decades ago from a common ancestor shared with diversity sampled
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Chemical Dissection of Selective Myeloid Leukemia-1 Inhibitors: How They Were Found and Evolved Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-15 Luyao Wang, Yuxiang Chen, Maoqian Zhang, Jin Liu, Haozhe Li, Menghui Liu, Shuyun Wu, Yongmin Zhang, Wei Li, Bo Wang
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Structure-based Development of N-Arylindole Derivatives as Pks13 Inhibitors against Mycobacterium Tuberculosis Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-15 Xuan Zhang, Shichun Lun, Yu-Xin Li, Wei Zhang, Ruo-Yi Zhou, Ting Liu, Fan Yang, Jie Tang, , Li-Fang Yu
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Long-acting PrEP prevents HIV in women Nat. Med. (IF 58.7) Pub Date : 2024-12-13 Karen O’Leary
Original reference: N. Engl. J. Med. 391, 1179–1192 (2024)
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The harms of ultra-processed foods Nat. Med. (IF 58.7) Pub Date : 2024-12-13 Karen O’Leary
Original reference: BMJ 384, e077310 (2024)
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First tumor-agnostic approval for an ADC Nat. Med. (IF 58.7) Pub Date : 2024-12-13 Karen O’Leary
In April, the HER2-targeting antibody–drug conjugate (ADC) trastuzumab deruxtecan was granted accelerated approval by the US Food and Drug Administration for the treatment of unresectable or metastatic HER2-positive solid tumors. After an initial approval in 2019 for this drug for the treatment of patients with unresectable or metastatic HER2-positive breast cancer, the recent tumor-agnostic approval
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Multi-organ benefits of incretin agonists Nat. Med. (IF 58.7) Pub Date : 2024-12-13 Karen O’Leary
Following successful clinical trials and approvals for weight loss, accumulating evidence reported this year supports positive effects of incretin agonists — including semagludide (a GLP-1 receptor agonist) and tirzepatide (a dual GLP-1 and GIP receptor agonist) — on cardiovascular and kidney function. The FLOW trial showed that in patients with type 2 diabetes and chronic kidney disease, those treated
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From clinical to biological definitions of neurological diseases Nat. Med. (IF 58.7) Pub Date : 2024-12-13 Karen O’Leary
February saw the release of revised criteria for the diagnosis and staging of Alzheimer’s disease (AD) by the Alzheimer’s Association Workgroup, to align with recent scientific advances — including the approval of therapies that target AD pathology, and the development of reliable and accessible biomarkers. The new criteria define ‘core’ (specific to AD) and ‘non-core’ biofluid and imaging-based biomarkers;
更新日期：2024-12-20
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