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Predictive Methodology for Selecting the “Fit-for-Purpose” LC-HRMS Method for Quality Assessment in Peptide Synthesis Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-20 Pavan Ingle, Naveen Chandrasekar, Sumit Kumar, Cherukuri Venkata Apparao, Bichismita Sahu, Ravi P. Shah
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Thank You Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-20 Kai Rossen
My term as Editor-in-Chief for Organic Process Research & Development comes to an end in December 2024. I had the great honor to take over this role from Trevor Laird 10 years ago. Trevor had started the journal almost 20 years before and brought it into the family of American Chemical Society journals. The process chemistry community should be grateful to Trevor for having realized the need for a
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Three-Step Continuous Flow Synthesis of the Intermediate 4-Fluoro-2-methoxy-5-nitrophenol of Linzagolix Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-18 Tengfei Gong, Fei Ji, Yichen Shi, Yiyang Dong, Yu Xia, Fawen Wu, Xiaoming Zha
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Pd-Catalyzed Miyaura Borylations Mediated by Potassium Pivalate with Alcohol Cosolvents Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-17 Jacob M. Ganley, Senjie Ma, Cheng Peng, Eric M. Simmons
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Thermal Decomposition Properties and Thermal Hazard Assessment of Di(2,4-dichlorobenzoyl) Peroxide (DCBP) Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-17 Juanni Zhou, Chen Zhao, Lijing Zhang, Gang Tao
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Electrochemical Synthesis of an N-Arylpyridazinone: Discovery and Scale-Up Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-17 Chris C. Scarborough, Michael Dieckmann, Stanley C. S. Lai, Ralf Kohlbrenner, Matthias Lehmann, Claudio Battilocchio, Antonio Pedrina, Helmars Smits, Patrik Stenner, Tobias Stadtmueller
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Scalable Process Development of Ceritinib: Application of Statistical Design of Experiments Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-17 Shravan Kumar Komati, Amarendhar Manda, Sridhar Vasam, Gopal Chandru Senadi, Arthanareeswari Maruthapillai, Rakeshwar Bandichhor
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Overview and Recent Advances in the Purification and Isolation of Therapeutic Oligonucleotides Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-16 Aljaž Abe, Zdenko Časar
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Use of Population Balance Modelling to Derisk Scale-Up of an Integrated Crystallization–Wet Milling Process Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-16 Tamar Rosenbaum, Andrew Werneth, Shasad Sharif, Troy Wilkens, Benjamin Cohen, Joshua D. Engstrom, Antonio C. Ferretti, Yash Melkeri
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Synthesis, Characterization, and Control Strategies for Cabazitaxel-Related Substances at Scale Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-16 Amarendhar Manda, Shravan Kumar Komati, Debjit Basu, Gopal Chandru Senadi, Arthanareeswari Maruthapillai, Rakeshwar Bandichhor
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High-Throughput Experimentation Reveals Scope and Limitations of Selective Phosphine Reductants and Enables One-Pot mAb Reduction/Conjugation Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-13 Marion H. Emmert, Cuixian Yang, Eugene E. Kwan, Rebecca Chmielowski, Bruce Kilgore, Zachary L. VanAernum, Cecilia Bottecchia, Rodell C. Barrientos, Monica Haley, Kelly Raymond, Michael Rauscher, Zachary D. Dunn, Jay Desai
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Exploration for Chemical Filter Cartridges that Can Reduce Nitrogen Oxides, a Common Factor in the Formation of Nitrosamines Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-12 Ryota Nomura, Takahiko Taniguchi, Kazuya Suzuoki, Rintaro Yokoi, Kanenao Akasaki, Kyoko Hirai, Osamu Uchikawa
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Development of an Inherently Safe and Scalable Nickel-Catalyzed Borylation Process of an Aryl Sulfamate Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-12 Matthew V. Joannou, Christopher Y. Bemis, Geoffrey E. Purdum, Candice L. Joe, Kyle Eckenroad, Sharla L. Wood, Shasha Zhang, Amy A. Sarjeant, Rebecca A. Green, Jeffrey Nye, Steven R. Wisniewski, Scott A. Savage
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Robust Liquid Chromatography–Mass Spectrometry Determination of Deuterium Isotopologues for Quality Control of Deucravacitinib Using Nominal Mass Instrumentation Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-11 Cong Bi, Yueer Shi, Wei Ding, James Chadwick, Yan Zha, Su Pan, Paul Foy, Nicola Hulme, Brent Kleintop
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Can Ultrasound Replace Seeding in Flow Reactive Crystallization of an Aromatic Amine? Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-10 Biyu Zhang, Georgios D. Stefanidis, Tom Van Gerven
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Some Items of Interest to Process R&D Chemists and Engineers Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-10 James A. Schwindeman, Alex Kosanovich, Christopher B. Kelly, Timothy Kwok, Annabel Q. Ansel, James M. MacDougall, Jimmy Lauberteaux, David Philip Day, Elizabeth M. Dauncey, Sylvain Guizzetti, John Knight
This article has not yet been cited by other publications.
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Optimizing Industrial Solid-Phase Peptide Synthesis: Integration of Raman Spectroscopy as Process Analytical Technology Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-10 Michael A. Stager, Carlos Peroza, Julien Villaumie, Christopher Bilham, Cameron Desmond, Marcus Harris, Ramya Sambasivan, Gary Rowe, Lin Chen, Charles Tucker
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Regulatory Highlights Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-09 Andrew Teasdale, Cristiana Campa, Olivier Dirat
This article has not yet been cited by other publications.
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A Tribute to Ullmann’s Work: Expanding Copper Coil Reactor Applications toward the Hydroxylation of Aryl Bromides Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-08 Maite Molins, Javier Fernandez-Garcia, Xavier Berzosa
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Recent Advances in Nonprecious Metal Catalysis Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-07 David J. Bernhardson, Aran K. Hubbell, Robert A. Singer, Robert Szpera, Sergei Tcyrulnikov, Anna Chiara Vicini, Christophe Allais
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Why and How to Control P-Chirality in Phosphorothioated Therapeutic Oligonucleotides: Analytical Challenges Associated with Determination of Stereochemical Composition Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-06 Tanja Poredoš, Marko Trampuž, Tjaša Gornik, Klemen Naveršnik, Maša Sinreih Tisnikar, Samo Pirc, Zdenko Časar
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Evaluating Resonant Acoustic Mixing as a Wet Granulation Process Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-06 Matthew Frederick Lopez Villena, Zachary Dean Doorenbos, Kyle Thomas Sullivan, Blair Brettmann
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An Improved Commercial Process for the Preparation of Lifitegrast Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-06 Arvind Girkar, Dujon Noronha, Prashant B. Patil, Mustapha Mandewale, Sudhir Sawant, Mohan Anand Chandavarkar, Kishor More
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Scale-Up of Continuous Metallaphotoredox Catalyzed C–O Coupling to a 10 kg-Scale Using Small Footprint Photochemical Taylor Vortex Flow Reactors Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-04 Rodolfo I. Teixeira, Toby H. Waldron Clarke, Ashley Love, Xue-Zhong Sun, Surajit Kayal, Michael W. George
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Safe and Sustainable Industrial-Scale Production of Anhydrous Diazomethane via a Fully DCS/SIS-Controlled Continuous Flow System: Synthesis of α-Haloketones Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-02 Limin Que, Hanrong Yang, Zhigang Lin, Jie Zheng
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Screening Platform for Immobilized Biocatalysts Utilizing Miniature Rotating Bed Reactors Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-01 Jan-Ole Kundoch, Daniel Ohde, Emil Byström, Andreas Liese
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Optimization and Scale-Up Synthesis of a Lappaconitine Alkaloid Derivative, QG3030, as a Novel Osteoanabolic Agent Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-11-29 Heung Mo Kang, Chang Sang Moon, Yunchan Nam, Jiwoong Lim, Jiewan Kim, Tae-Hee Lee, Junho Lee, Mun Seog Chang, Jae Yeol Lee
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Process Development to Synthesize SGD-11275 Utilizing a Pd-Catalyzed Acetamide Arylation and Gallium-Mediated Friedel–Crafts Acylation Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-11-26 Tristan M. McGinnis, Noah Porter, Apparao Bokka, Kun-Liang Wu, Brooke Gill, Jared Abbruzzese, Aaron M. Whittaker, Srinath Thirumalai rajan
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Atom-Economical and Environmentally Friendly Bts-Based Purine PNA Monomers without Base-Protecting Groups Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-11-25 Minji Kim, Hyewon Hwang, Yong-Tae Kim, In Seok Hong
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Development of a Scalable Method for the Synthesis of Ethoxy(pentafluoro)cyclotriphosphazene Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-11-21 Lijun Zhu, Desheng Zhang, Zilong Li, Raoling Ge, Banglong Wan, Qiang Tian, Pengfei Xu
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Practical and Efficient Approach to Scalable Synthesis of Rucaparib Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-11-15 Jinjae Park, Cheol-Hong Cheon
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Practical, Large-Scale Preparation of Ni(tmeda)(o-tol)Cl Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-11-15 Morgan E. John, Daven Foster, Stephen A. Moggach, George A. Koutsantonis, Reto Dorta, Scott G. Stewart
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Chemical and Biochemical Approaches to an Enantiomerically Pure 3,4-Disubstituted Tetrahydrofuran Derivative at a Multikilogram Scale: The Power of KRED Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-11-14 Antony Bigot, Alain Rabion, Jean-Bernard Landier, Geoffrey Laronze, Frédéric Petit, Stéphanie Deprets, Jean-Marc Michot, Changxia Yuan, Fenglai Sun, Han Chen, Longlei Hou, Dalin Tang
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A Journey through Process Development Enhanced by Kinetic Modeling: An Efficient Manufacturing Route to Balcinrenone Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-11-13 Cristina García-Morales, David Dave, Zeina Neouchy, Helen Pointon, Matthew J. Foulkes, Alice Page, Thomas O. Ronson, Robert J. Cox
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Identification of a Novel Process Impurity, Root Cause Investigation, and Its Control Strategy in Process Chemistry of Nevirapine API Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-11-12 Jinsheng Lin, Xiaojian Zheng, Dan Li, Huacui Hou, Xinlei Chen, Jianyang Jin, Xianhua Zhang, Wenbin Chen, Min Li
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Process Development for the Manufacture of a Topical Pan-Trk Inhibitor Incorporating Decarboxylative sp2–sp3 Cross-Coupling Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-11-12 Michael S. Ashwood, Edward I. Balmond, David Fengas, Jane McGuffog, Jonathan Moore, Nicola M. Robas, Neil G. Stevenson, Lisa Wise
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Step-Economic Synthesis of Tamsulosin Hydrochloride via Continuous Chlorosulfonation and Biocatalytic Transamination Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-11-11 Ágnes Malta-Lakó, Raquel M. Durão, László Poppe, Ricardo F. Mendonça
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Enabling Data-Driven Solubility Modeling at GSK: Enhancing Purge Predictions for Mutagenic Impurities Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-11-11 Luigi Da Vià, Matthias Depoortere, Robert D. Willacy, Alastair J. Roberts, Pandian Sokkar, Mathieu Fossépré, Andrew Ruba, Magdalena A. Zwierzyna
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An Analysis of Published Synthetic Routes, Route Targets, and Reaction Types (2000–2020) Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-11-11 Samuel Genheden, Gareth P. Howell
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Veliparib: Analytical Tools and Process Design Strategies for the Control of Mutagenic Impurities and Other Drug Substance Critical Quality Attributes Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-11-08 Rajarathnam E. Reddy, David M. Barnes, Adam P. Schellinger, Travis B. Dunn, Lawrence Kolaczkowski, Wayne A. Pritts, Yao-En David Li, Samrat Mukherjee, Andrew Staley
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Asymmetric Synthesis of the cis-1,2-Diaryltetralin Vepdegestrant Core via an Enantioselective Intramolecular Corey-Chaykovsky Epoxidation Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-11-08 David J. Bernhardson, Sarai Lara-Boykin, James Christopher McWilliams, Yexenia Nieves-Quinones, Liam S. Sharninghausen, Robert A. Singer, Zheng Wang, Zebediah C. Girvin
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Building and Evolving a Chiral Control Strategy for Accelerated COVID Programs Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-11-08 Christophe Allais, Aaron F. Baldwin, Hugh J. Clarke, Christina G. Connor, Michael Coutant, Cindy Duong, Michael Herr, Chintelle James, Maciej Kalinowski, Johnny W. Lee, Yizhou Liu, Jared L. Piper, John A. Ragan, John J. Salisbury, R. Matthew Weekly, Shu Yu, Mengtan Zhang
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Thermodynamically Controlled and Industrially Viable Telescopic Process for the Synthesis of Fluazuron Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-11-07 Dattatray Patil, Rakesh R. Ganorkar, Ramakant Kardile, Madhavrao Bhoite, Amol Jadhav, Rutuja Gundal, Garbapu Suresh
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Optimized Synthesis of an Abemaciclib Intermediate: Improved Conditions for a Miyaura Borylation/Suzuki Coupling Process Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-11-07 Michael P. Carroll, Aobha Hickey, Ava Rogers, Cáoimhe J. Niland, Rachel A. O’Sullivan, Nachimuthu Muniraj, Kevin F. O’Sullivan, Patrick J. Guiry, Michael M. Murray
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Development of a Commercial Manufacturing Process for Vepdegestrant, an Orally Bioavailable PROTAC Estrogen Receptor Degrader for the Treatment of Breast Cancer Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-11-05 Steve Avery, Jamie M. Buske, Doris Chen, Herman Chen, Xin Chen, Andrew R. Davidson, Jean-Nicolas Desrosiers, Hanqing Dong, Noalle Fellah, David F. Fernández, John Grosso, Lu Han, Teri Hochdorfer, Amber M. Johnson, Brian P. Jones, Maciej Kalinowski, Katherine D. Launer-Felty, Jorge Lopez, Teresa Makowski, Carolyn Mastriano, Truong N. Nguyen, Nitinchandra D. Patel, Zhihui Peng, Tyler Potter, Robert P
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Early Process Development of an LPAR1 Antagonist, GS-2278 Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-11-05 Nathaniel Kadunce, Anna M. Wagner, Jeromy Cottell, Kathy Dao, Darryl D. Dixon, Blanka M. Hodur, Dane Holte, Michael A. Ischay, Jihun Kang, Seongtaek Kim, Young Ho Kim, Seung Moh Koo, Willard Lew, Lucas Man, Kashi Reddy Methuku, Henry Morrison, Patrick D. Parker, David A. Siler, Chloe Y. Wong
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Some Items of Interest to Process R&D Chemists and Engineers Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-11-05 Alan Steven, Carlos Mateos, Andrei A. Zlota, Paul F. Richardson, Robert B. Kargbo, Thomas Verheyen, Christopher C. Nawrat, David S. B. Daniels, Alexandre Barthelme, John Knight
This article has not yet been cited by other publications.
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Continuous Flow Enabled Synthesis of Multiresistant Drug Clofazimine Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-11-01 Rajat Pandey, Faith Akwi, Paul Watts
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One-Pot Synthesis of Guanidinium 5,5′-Azotetrazolate Avoiding Isolation of Hazardous Sodium 5,5′-Azotetrazolate Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-10-30 Miroslav Labaj, Zdeněk Jalový, Robert Matyáš, Jiří Nesveda, Jakub Mikuláštík, Adam Votýpka
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Tris(trimethylsilyl)silane in Photochemical Hydrodesulfurization─Methodology and Pyrophoricity Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-10-30 Michaela Čierna, Blažej Horváth, Filip Pančík, Michal Šoral, Andrej Kolarovič, Pavol Jakubec
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Industrial-Scale Organic Solvent Nanofiltration for Dimer Impurity Removal: Enhancing Vitamin D3 Production Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-10-25 Jan Schütz, Julia Witte, Maurus Marty, Roman Goy
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Continuous Sonocrystallization Process for Controlling the Polymorphs and Particle Size of Perampanel Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-10-23 Koji Machida, Koichi Igarashi, Hideo Kawachi, Mai Okamoto, Shumpei Yonezawa, Yuka Morishige, Masayuki Azuma, Akira Nishiyama
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Practical One-Pot Synthesis of 2-Alkyl-Substituted Benzothiazoles from Bis-(2-nitrophenyl)-disulfides Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-10-23 Volodymyr O. Puskov, Serhii B. Babii, Iryna V. Adamenko, Sviatoslava O. Melnychuk, Tetiana V. Druzhenko, Alexander Yu. Lyapunov, Sergii V. Popov, Dmytro M. Volochnyuk, Serhiy V. Ryabukhin
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Selective Synthesis of N6,3′,5′-Tripivaloyladenosine via Dynamic Kinetic Crystallization and Regioselective Preparation of Pivalated 2′-Deoxy-2′-fluoroarabinoadenosines Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-10-23 Peter E. Maligres, Zhiguo Jake Song, Lu Chen, Birgit Kosjek, Omer Ad, Cheol K. Chung
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Facile Recovery and Recycling of a Soluble Dirhodium Catalyst in Asymmetric Cyclopropanation via a Catalyst-in-Bag System Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-10-23 UnJin Ryu, Duc Ly, Kristin Shimabukuro, Huw M. L. Davies, Christopher W. Jones
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Electrochemical Trifluoromethylation of Enamides under Microflow Conditions Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-10-22 Anna Vanluchene, Tomas Horsten, Eli Bonneure, Christian V. Stevens
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Electrochemical Cyclopropanation of 1,3-Dialkyl Bromides Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-10-22 Sylvain Charvet, Clément Jacob, Aurore Dietsch, Guillaume Tintori, Pierre-Georges Echeverria, Julien C. Vantourout
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Development of a Scalable Manufacturing Process for Alectinib with a Concise Preparation of the Indole-Containing Tetracyclic Core Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-10-22 Tomohiro Oki, Masao Tsukazaki, Junichi Shiina, Hiroshi Fukuda, Minoru Yamawaki, Yasushi Kito, Takenori Ishizawa, Kazutomo Kinoshita, Sosuke Hara, Noriyuki Furuichi, Hatsuo Kawada, Toshiya Ito, Kota Tanaka, Noriaki Maruyama, Daisuke Tamaru, Takahiro Ichige, Masatoshi Koizumi, Yosuke Hosoya, Masahiro Kimura, Mami Yamaguchi, Shigeki Sato, Yuta Miyazaki, Azusa Toya, Hiroshi Iwamura, Kenji Maeda
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Solving Gas–Liquid Mixing-Induced Clogging in Continuous-Flow Hydrogenation Synthesis of an API Intermediate Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-10-21 Jadid E. Samad, Douglas Connolly, Zheng Zhao, Joel M. Hawkins
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Expansion of the Green Chemistry Principles: Inclusion of Greenhouse Gases and Carbon Footprint Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-10-18 Kai Rossen, Krishna Ganesh, Kai Oliver Donsbach
There is growing agreement among scientists that the world may face catastrophic climatic developments in the coming decades, caused primarily by the massive emission of greenhouse gases such as CO2 and methane. Many governments are already beginning to face the challenge on how to manage and minimize the calamitous effects. The topic is a complex interplay of many facets, and the sheer size of the
更新日期：2024-12-17
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