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Use of Impinging Jet to Improve Scalability in the Preparation of the ABBV-154 Drug-Linker Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-06-28 Nathan B. Bennett, Laurie B. Mlinar, Eric G. Moschetta, Ryan G. Ellis, Ryan Chung, Onkar Manjrekar, Michael Rasmussen, Laura A. McKee, Mark A. Servos, Justin A. Simanis, Bradley D. Gates, Xiaoqiang Shen, Dennie S. Welch, Zhe Wang
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Proprietary Synthesis of the C27–C35 Fragment of Eribulin and Its Elaboration toward the C14–C35 Subunit Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-06-28 U Bin Kim, Srinivas Samala, Jaehun Jung, Juyoung Song, Kee-Young Lee, Chang-Young Oh, Hyunik Shin
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Micelle-Enabled Hofmann Rearrangement in Water Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-06-28 Xiaoqi Xing, Kangming Zhao, Zhidong Li, Ning Ye, Nan Zhao, Fengfeng Guo, Chunhua Qiao, Guoqiang Xu, Michael Parmentier, Fabrice Gallou, Bin Wu
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Chemoselective Saponification in the Synthesis of Danuglipron Facilitated with Trifluoroethanol Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-06-27 Lu Han, Bryan Li, Ke Wang, David B. Damon, Javier Magano, Mark T. Maloney, Jason Mustakis, Ronald J. Post, Ruizhi Li, Truong Nguyen
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HTE OS: A High-Throughput Experimentation Workflow Built from the Ground Up Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-06-27 Georg Wuitschik, Vera Jost, Torsten Schindler, Michal Jakubik
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PAT-Enabled Automated Feedforward Control: An Application to the Continuous Manufacture of Apremilast Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-06-25 Hsiao-Wu Hsieh, Daniel J. Griffin, Anirudh M. K. Nambiar, Nandini Sarkar, Hamza Youssef Ismail, Kartik Saigal, Dongying Erin Shen, Nicole Goudas-Salomon, Rasangi Wimalasinghe, Alicia Zeng, Oliver R. Thiel, Matthew G. Beaver
Previously, we reported the development and characterization of an integrated continuous manufacturing (CM) process for the penultimate step in the synthesis of apremilast, the drug substance of Otezla. Herein, we report the application of closed-loop control to this CM process as a case study. A Python-based feedforward closed-loop controller is developed that uses infrared (IR) process analytical
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Development and Execution of a Scalable Route to an Immunology ADC Drug-Linker for ABBV-154 Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-06-25 Nathan B. Bennett, Xiaoqiang Shen, Bradley D. Gates, Dennie S. Welch, Mark A. Servos, Justin A. Simanis, Ryan G. Ellis, Haixiao Qiu, Eric G. Moschetta, Jiajie Feng, Moussa Boukerche, Michael Rasmussen, Laura A. McKee, Laurie B. Mlinar, Shuang Chen, Zhe Wang
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First Deliveries of API Enabling Early Drug Development Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-06-21 Aaron C. Sather, James J. Douglas
This article is part of the First Deliveries of API Enabling Early Drug Development special issue. The discovery and development of a new drug is a long and arduous process, with more failures realized than successes. (1) Although technological advancements coupled with improved experimental techniques such as high-throughput experimentation, (2) library screening, and data-rich experimentation (3)
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Process Intensification via End-to-End Continuous Manufacturing of Atorvastatin Calcium Using an Integrated, Modular Reaction-Crystallization-Spherical Agglomeration-Filtration-Drying Process Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-06-20 Rojan Parvaresh, Zoltan K. Nagy
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Novel and Convenient Synthesis of Deoxycholic Acid from Cholic Acid Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-06-17 Xinkun Wang, Qingyuan Hu, Xiao Ma, Guojing Li, Hong Yan, Yu Liu
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Scale-Up Investigation of Aggarwal Enal Bicyclic Intermediate Synthesis Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-06-18 Andrejs Pelšs, Kirill Shubin
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New Method to Large-Scalable Preparation of the Key Chiral Cyclohexane cis-Diamine Intermediate for Edoxaban Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-06-14 Dingding Yuan, Qiujun Peng, Wenwen Xia, Wansheng Yu, Libo Ruan, Yaping Wang, Yu Chen, Xianhua Pan
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Continuous-Flow Solid-Phase Peptide Synthesis to Enable Rapid, Multigram Deliveries of Peptides Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-06-14 Kyle E. Ruhl, Michael J. Di Maso, Harrison B. Rose, Danielle M. Schultz, François Lévesque, Shane T. Grosser, Steven M. Silverman, Shasha Li, Nunzio Sciammetta, Umar Faruk Mansoor
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Nitrite in Pharmaceutical Manufacturing Water: Development of an Ultra-Sensitive Analytical Method, Typical Data, and Discussion of Potential Nitrosamine Formation in Drug Substance and Drug Product from Water Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-06-12 A. B. Suresh Kumar, Debasis Dey, T. S. Balaji, Haridoss Karthik, K. Sathishkumar, Paul McDaid, Brian Fitzpatrick, Atul Awasthi, Simon Davies, Olivier Dirat
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Development of a Cryogenic Flow Reactor to Optimize Glycosylation Reactions Based on the Active Donor Intermediate Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-06-11 Vanessa A. Jones, Gideon Q. Bennett, Jennifer R. Pierre-Louis, Clay S. Bennett
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Route Design and Scale-Up of a Topoisomerase I Inhibitor Antibody–Drug Conjugate Payload Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-06-11 William R. F. Goundry, Andrew M. Poulton, Matthew Welham, Kuangchu Dai, Xiaohong Zhu, Haijun Tao, Canlin Tang, Fanny Magne, Bertrand Cottineau
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Some Items of Interest to Process R&D Chemists and Engineers Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-06-11 James A. Schwindeman, Alex Kosanovich, Christopher B. Kelly, Timothy Kwok, Elizabeth Dauncey, Annabel Q. Ansel, James M. MacDougall, Jimmy Lauberteaux, David Day, Sylvain Guizzetti, John Knight
This article has not yet been cited by other publications.
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Streamlined Three-Step Telescope Enabled by a Nonaqueous Suzuki–Miyaura Cross-Coupling Reaction Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-06-10 Rebecca A. Green, Jeishla L. Meléndez Matos, Eric M. Simmons, Bahar Inankur, Brian L. He, Jennifer Lott, Shasha Zhang, Sergei Kolotuchin, Damián Reyes-Luyanda, Peng Geng, Jason M. Stevens, Jeffrey Nye, Michelle Kubin, Sha Lou, Albert J. DelMonte, Ling Zhang, Neil A. Strotman
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Technology Transfer and Process Development of Danicopan to Enable Process Validation Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-06-07 Yangmu Chloe Liu, Suresh K. Tipparaju, Michael R. Tracey, Robert Carr, Anil Damarancha, Akihiro Hashimoto, Stephen Hubbs, Chad Keyes, John Lucas, Vidya Nandialath, Mark Stevens, Mareena Thottakara
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Benchmarking Strategies of Sustainable Process Chemistry Development: Human-Based, Machine Learning, and Quantum Mechanics Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-06-06 A. Filipa Almeida, Sofia Branco, Luisa C. R. Carvalho, Andre Raposo Moreira Dias, Emília P. T. Leitão, Rui M. S. Loureiro, Susana D. Lucas, Ricardo F. Mendonça, Rudi Oliveira, Inês L. D. Rocha, Joao Sardinha, Saúl Silva, Luís M. S. Sobral, Nuno M. T. Lourenço, Pedro C. Valente
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First Multikilogram Synthesis of the Next-Generation Oral Selective ERα Degrader Camizestrant Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-06-07 Matthew R. Tatton, Gordon S. Currie, Bradley Adams, Carl-Johan Aurell, Karl Broberg, Andrew D. Campbell, Kuangchu Dai, Marcus Malmgren, Andrew Ikin, Sophie L. M. Janbon, Martin Sims, Joanna Hemming-Taylor, Victoria Winterbottom
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Process Development of a Tricyclic Diazepine-Based IDH1 Mutant Inhibitor Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-06-06 Matthew L. Maddess, Ed Cleator, Mariko Morimoto, Adrian Goodyear, Alejandro Dieguez-Vazquez, Andrew Gibb, Andy Kirtley, Melodie Christensen, Chaohui Song, Feng Peng, Mahbub Alam, Stephen P. Keen, Steven F. Oliver
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Rapid End-Game Process Development and First GMP Production of MK-7845: An Experimental Antiviral Treatment for COVID-19 Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-06-06 Nicholas R. Deprez, Jonathan M. E. Hughes, Shorouk O. Badir, Stasik Popov, Teresa Andreani, Rachel S. Bade, Clara Hartmanshenn, Thomas Tai-min Kwok, Donald R. Gauthier, Jr., Nastaran Salehi Marzijarani, Zeinab Sakhaei, Riki Drout, Steve Castro, David J. Schenk, Charles Wolstenholme, Nilusha Padivitage, Cody Welch, Jason R. Kowalski, Brittany Kassim, Yong Liu, Ryan D. Cohen, Alex M. Confer, Guilherme
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Scalable Synthesis of 6-Chloro-1H-pyrazolo[3,4-b]pyrazine via a Continuous Flow Formylation/Hydrazine Cyclization Cascade Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-31 Thomas M. Bass, Daniel Zell, Sean M. Kelly, Thomas C. Malig, José G. Napolitano, Lauren E. Sirois, Chong Han, Francis Gosselin
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Copper-Catalyzed Hydroxylation of Aryl Halides Using Hydroxypicolinamide Ligands Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-30 Daniel W. Widlicka, Robert A. Singer, Ian Hotham, David J. Bernhardson, Samantha Grosslight
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Thermal Stability of Tetrahydroxydiboron Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-30 Shasha Zhang, Simon Shun Wang Leung, Dale Vanyo
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The First GMP Synthesis of MK-2118, a Small Molecule Agonist for Stimulator of Interferon Genes Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-30 Thomas. W. Lyons, David A. Thaisrivongs, Nadine Kuhl, Cheol K. Chung, Angie Angeles, Dietrich Steinhuebel, Erik Guetschow, Andrew P. J. Brunskill, Timothy J. Henderson, Brandon D. Cash, Andrew Haidle
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Large-Scale Tandem Cyclization Applied to Potentially High-Volume SSTR4 Agonists Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-29 Louise M. Guard, John R. Rizzo
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Supervised Machine-Learning Algorithm using Low Data Sets: Flow Chemistry Optimization of the Key Urea Moiety Construction in Larotrectinib Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-28 Haripriya Thalla, Varshini Uma Jayaraman, Maheshkumar Uppada, Vishnuvardhan Reddy Eda, Saikat Sen, Rakeshwar Bandichhor, Srinivas Oruganti
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Development of New Catalytic Asymmetric Routes toward a Cost-Driving Building Block of Nirmatrelvir Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-28 Robert Szpera, Shanjun Huang, Harriet A. M. Fenton, William Waddington, Adam E. S. Gymer, Ian B. Moses, Julia Buck, Heather Ingram, Steven J. Fussell, Robert Walton, Charles S. Shanahan, Sarah L. Aleshire, Juliana M. S. Robey, Hanuman P. Kalmode, Michel C. Nuckols, Nageswara R. Kalikinidi, Venumadhav Janganati, Sipak Joyasawal, Chanaka M. Amarasekarage, Chris H. Senanayake, B. Frank Gupton
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Thank You, Steve Ritter! Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-27 Stefanie Dehnen, Paul J. Chirik, Marisa Kozlowski, Scott Miller, Kai Rossen
Stephen K. Ritter is the best-kept secret for the success of five ACS journals! Most readers and authors of our journals do not realize that there is a dedicated and talented team behind the scenes. As the Senior Managing Editor of Inorganic Chemistry, Organometallics, Organic Letters, The Journal of Organic Chemistry, and Organic Process Research & Development over the years, Steve is the epitome
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Compatibility Study between 50% H2O2/H2SO4 Solution and Some Common Organic Solvents Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-24 Shichun Weng, Juan Zhou, Yingtao Tian, Xigui Jiang, Rong Chen, Jinyao Hu, Zichao Guo, Liping Chen, Wanghua Chen
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Process Development of the Pyrazinecarboxamide Component of Gilteritinib, a FLT3 Inhibitor Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-24 Toshiyuki Sugimori, Takahiro Akiba
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Development of Asymmetric Reductive Amination of Unfunctionalized Ketone with Primary Amine Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-22 Xiangyu Liu, Ensheng Zhan, Zhi Wang, Guoliang Dong, Gaochao Dong, Shuai Wu, Yunlin Zhang, Jingrui Chen, Jialin Wen, Lei Zhang
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Solvent Switching in Continuous Multistep Chemoenzymatic Synthesis: Telescoping Enzymatic Synthesis of Chiral, Pyridine-Containing Amines with Cross-Coupling as a Case Study Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-21 Pablo Díaz-Kruik, David Roura Padrosa, Eimear Hegarty, Hansjoerg Lehmann, Radka Snajdrova, Francesca Paradisi
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Comprehensive Analysis on the Synthesis Methods of 2-Phenylindole Derivatives with Pharmacological Importance for Green Synthesis Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-21 Pan Wu, Xuelian Shen, Junxi Zhao, Xiaoxia Liang
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Ketoreductase-Mediated Stereodivergent Synthesis of 1,1-Disubstituted Cyclobutan-3-ols Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-21 Hardwin O’Dowd, Olivia M. Morales
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Development of a First-Generation Stereocontrolled Manufacturing Process of TRPA1 Inhibitor GDC-6599 Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-23 Allen Y. Hong, Katarzyna A. Piechowicz, Jacob C. Timmerman, Haiming Zhang, Carmela Molinaro, Francis Gosselin
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Development and Scale-Up of 7-COOH CBD Synthesis, a Key Cannabinoid Metabolite Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-14 Mark Austin, Peter Cairns, Darren Conboy, Guang Xing Wang, Thomas S. Moody, Megan Smyth, Scott Wharry, Bernard T. Golding, Alistair P. Henderson, Philip Butler, Manuel Monerris Mascaro, Manuel Abelairas-Edesa, Alberte Xose Veiga Corral, Hannah Straker
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Flow Chemistry and Continuous Processing: More Mainstream than Ever! Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-17 Kevin P. Cole, Jonathan N. Jaworski, C. Oliver Kappe, Shu Kobayashi, Anita R. Maguire, Anne O’Kearney-McMullan, Jaan A. Pesti
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Early Kilogram Scale Delivery of MK-7845 as a Potential COVID-19 Therapy: Rapid Process Development of Key Intermediates Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-16 Feng Peng, Ji Qi, Jin Zhang, Enkai Wang, Xiaohui Cao, Lu Chen, Chao Fan, Wei Fan, Cheng Feng, Mingxiang Lin, Mingjie Liu, Christopher C. Nawrat, Danielle M. Schultz, Chaohui Song, Feng Wang, Jingjun Yin, Yuming Zhang
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Kilo-Scale Synthesis of the Dinucleotide DNA Methyltransferase Inhibitor Guadecitabine Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-10 Matthew Johnson, Ramakrishnan Chidambaram, Nipun Davar, Christian Madsen, Yogesh S. Sanghvi, Robert Short
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Development of a Scalable Alkylation via a Protection/Deprotection Sequence for BMT-773752: Key Intermediate in the Synthetic Route to Repotrectinib Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-08 Han Zhang, Binfeng Li, Jin Yang, Changchun Xu, Rafaela Carmona, Jason Zhu, Bilal Hoblos, Steven Wisniewski
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Process Intensification of the Continuous Synthesis of Bio-Derived Monomers for Sustainable Coatings Using a Taylor Vortex Flow Reactor Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-09 Matthew D. Edwards, Matthew T. Pratley, Charles M. Gordon, Rodolfo I. Teixeira, Hamza Ali, Irfhan Mahmood, Reece Lester, Ashley Love, Johannes G. H. Hermens, Thomas Freese, Ben L. Feringa, Martyn Poliakoff, Michael W. George
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Pilot-Scale Operation and Characterization of an Organolithium-Mediated Coupling Reaction in Flow to Form a Ketone Intermediate on the Route to Nemtabrutinib Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-09 Robert D. Franklin, Travis Armiger, Douglas A. L. Otte, Reed T. Larson, Glenn Spencer, Pratiq A. Patel, Mellie June Paulines, Jackson R. Hall, Kai-Jiong Xiao, Patrick S. Fier, Vailankanni L. Rodrigues, Erik D. Guetschow, Nadine Kuhl, Lisa Jellett, James Corry, Cheol K. Chung, David A. Thaisrivongs
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Development of a Green and Sustainable Manufacturing Process for a Key Intermediate to Nemtabrutinib (MK-1026): Sequential Deprotonation–Lithiation as a Batch–Flow Process Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-09 Douglas A. L. Otte, Reed T. Larson, Embarek Alwedi, Travis Armiger, Yonggang Chen, Cheol K. Chung, James Corry, Richard Desmond, Patrick S. Fier, Robert D. Franklin, Erik D. Guetschow, Jackson R. Hall, Holst M. Halsey, Clara Hartmanshenn, Lisa Jellett, Nadine Kuhl, François Lévesque, Jonathan P. McMullen, Pratiq A. Patel, Mellie June Paulines, Hong Ren, Vailankanni L. Rodrigues, Serge Ruccolo, Lushi
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Development of Lab-Scale Continuous Stirred-Tank Reactor as Flow Process Tool for Oxidation Reactions Using Molecular Oxygen Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-08 Ursina Gnädinger, Dario Poier, Claudio Trombini, Michal Dabros, Roger Marti
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Continuous Crystallization Kinetics of Cefradine in a Mixed Suspension Mixed Product Removal System Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-07 Yueyi Yang, Chenxin Xie, Chuang Ma, Baoshu Liu, Xiaowei Cheng, Hongxun Hao, Hua Sun
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Scalable Protocol for Removing Triphenylphosphine Oxide from Reactions Using MgCl2 and Wet Milling Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-07 Eric G. Moschetta, Benoit Cardinal-David, Travis B. Dunn, Moiz Diwan
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Efficient, Scalable Synthesis of Functionalized Pyrrolo[2,1-f][1,2,4]triazines Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-07 Shawn K. Pack, Lei Feng, Ce Chen, Zhongzhen Li
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Kilogram-Scale Synthesis of 11β-Hydroxyandrosterone Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-06 Hossay Abas, Peter Blencowe, Ellen MacDonald, Emma Stanway, Eric P. A. Talbot, Haiyang Wang, Morag Watson, Jin Zhang, Lucy A. Harwood
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Design and Characterization of a Novel Continuous Annular Gap Crystallizer Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-07 Nico Nys, Lorenz Buchgraber, Peter Neugebauer, Matthew J. Jones, Heidrun Gruber-Woelfler
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A Coalescing Filter for Liquid–Liquid Separation and Multistage Extraction in Continuous-Flow Chemistry Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-06 James Daglish, A. John Blacker, Gregory de Boer, Stephen J. Russell, Muhammad Tausif, David R. J. Hose, Anna R. Parsons, Alex Crampton, Nikil Kapur
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Development of a Kilogram-Scale Manufacturing Route for Bis-Tac-dG: Essential Building-Block for Guadecitabine Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-03 Kirtee Wani, Shyamapada Banerjee, Nipun Davar, Yogesh S. Sanghvi
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Continuous Scalable Synthesis and Concentration Variation of Organozinc Compounds Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-02 Lars Gössl, Kai Dahms, Gabriele Menges-Flanagan, Michael Maskos
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Enantioselective Synthesis in Continuous Flow: Polymer-Supported Isothiourea-Catalyzed Enantioselective Michael Addition–Cyclization with α-Azol-2-ylacetophenones Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-02 Zhanyu Zhou, Kevin Kasten, Tengfei Kang, David B. Cordes, Andrew D. Smith
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Some Items of Interest to Process R&D Chemists and Engineers Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-02 Alan Steven, Carlos Mateos, Andrei A. Zlota, Alexandre Barthelme, Paul F. Richardson, Robert B. Kargbo, Thomas Verheyen, Christopher C. Nawrat, Sylvain Guizzetti, John Knight
This article has not yet been cited by other publications.
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Comprehensive Review on the Synthetic Strategies toward Anti-SARS-CoV-2 Drug Ensitrelvir Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-05-01 Yuanchang Liu, Gaorong Wu, Yiting Yang, Wei Hu, Xiaopeng Peng, Zihan Peng, Jiatao Xia, Xin Xie, Jiuzhong Huang, Weiming Chen
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Analytical Strategy for Low-Level Estimation of Unstable Genotoxic Boronate Ester Impurities Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-04-30 Bhoopendra Singh Kushwah, Santosh Gandhi, Devikumar Purandharan, Ashok Kumar Rajendran, Karthik Jayaraman, Venkata Phanikrishna Sharma Mangalampalli, Joel Young, Lakshmikant Bajpai
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Mechanistic Studies of Imidazole Autocatalysis in 1,1′-Thiocarbonyldiimidazole-Mediated Couplings of Aniline Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-04-30 Nathan March, Bradley J. Paul-Gorsline