Inflorescences of the female hop plant (Humulus lupulus L.) contain biologically active compounds, most of which have a bitter taste. Given the rising global obesity rates, there is much increasing interest in bitter taste receptors (TAS2Rs). Intestinal TAS2Rs can have beneficial effects on obesity when activated by bitter agonists. This study aims to investigate the mechanism of action of a hydroalcoholic hop extract in promoting hormone secretion that reduces the sense of hunger at the intestinal level through the interaction with TAS2Rs.

中文翻译：

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Humulus lupulus L.：植物化学特征和苦味受体激活以调节肠道促胰液素肿瘤细胞系（STC-1 细胞）食欲和饱腹感的评价


雌性啤酒花植物 （Humulus lupulus L.） 的花序含有生物活性化合物，其中大多数具有苦味。鉴于全球肥胖率的上升，人们对苦味受体 （TAS2R） 的兴趣日益浓厚。当被苦味激动剂激活时，肠道 TAS2Rs 可以对肥胖产生有益影响。本研究旨在探讨水醇啤酒花提取物通过与 TAS2Rs 的相互作用促进激素分泌而降低肠道饥饿感的作用机制。