样式: 排序: IF: - GO 导出 标记为已读
-
Front Cover: Direct Reductive N-alkylation of Amines with Carboxylic Esters (Eur. J. Org. Chem. 1/2025) Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-08
Yuxuan Zhang, Emmanuel Mintah Bonku, Xingbang Yang, Fuqiang Zhu, Xiangrui Jiang, Safomuddin Abduahadi, Peng Yang, Haji Akber Aisa, Jingshan Shen, Hongjian Qin -
Ruthenium-Zeolite Catalyzed Dehydrative N-Benzylation of Amides for the Construction of Macrolactams under Continuous Flow Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-09
Akash Bandu Jamdade, Gourishankar Bamayya Swami, Dashrat Vishambar Sutar, Padmavathy V. K. Nair, Boopathy GnanaprakasamContinuous-flow synthesis of acyclic amides and macrolactams has been demonstrated successfully via N-benzylation of amides using a highly reusable heterogeneous Ru-Zeolite as a catalyst, which gives only water as the byproduct. N-Benzylation of acyclic amides furnished 30 N-benzylated amides whereas intramolecular N-benzylation with alcohols was well tolerated with 15 examples of macrolactams bearing
-
Substitution pattern of the secondary rim of ICyD ligand influences stereoselectivity Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-08
Guangcan Xu, Olivia Bistri-Aslanoff, Virginie Mouriès-Mansuy, Louis Fensterbank, Yongmin Zhang, Sylvain Roland, Matthieu SollogoubThe synthesis and evaluation of an N-heterocyclic carbene (NHC)-capped cyclodextrin with various protecting groups were conducted. The corresponding gold complexes catalyzed the stereoselective cycloisomerization of enynes. Permethylation of the cyclodextrin’s hydroxyl groups improved yield and selectivity compared to its benzylated counterpart. Notably, alternating methyl and benzyl groups on the
-
NaI-promoted Synthesis of Dihydroquinolines via an Unusual Azetine Intermediate Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-08
Futong Li, Zhongxuan Qiu, Daoshan Yang, Longjiang Huang, Feifei XinNew approaches to improve Skraup-type reactions for large-scale synthesis of 1,2-dihydroquinolines (1,2-DHQs) are highly desirable yet challenging in synthetic chemistry. Herein, an efficient sodium iodide-promoted Skraup-type reaction of anilines with ketones has been developed at low loading of HBF4 (0.5 mol%), thus providing a sustainable and economical strategy for the synthesis of 1,2-DHQs. A
-
Microwave‐assisted multicomponent synthesis of spirooxindole dihydropyridine bisphosphonates Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-08
Bettina Rávai, Áron Soma Németh, Zsolt Kelemen, Erika BálintA new, simple, catalyst‐ and solvent‐free microwave (MW)‐assisted multicomponent method was elaborated for the synthesis of spirooxindole dihydropyridine bisphosphonates as a new family of compounds by the one‐pot reaction of isatins, β‐ketophosphonates and primary amines. The synthesis was carefully optimized in respect of the molar ratio of the starting materials, the heating mode, the temperature
-
Photoinduced, Decarboxylative Coupling of α‐Keto Acids with Diselenides to Form Selenoesters Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-06
Pei Qu, Haifan Wang, Ying Chen, Kanta Pajujantaro, Gong-Qing LiuA mild and green strategy for the synthesis of selenoester derivatives has been developed through photoinduced decarboxylative coupling of α‐keto acids with diselenides. This transformation proceeds smoothly without requiring any external photocatalyst, additive, or oxidant. Both diaryl and dialkyl diselenides react efficiently with α‐keto acids to produce selenoesters in good yields. Mechanistic studies
-
Synthesis of Enantioenriched 2‐((Hetera)cyclo)alkylchromanols and their Spirocyclic Analogs through Enzymatic Resolution Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-06
Oleksii S. Timokhin, Anastasiia M. Romanova, Viktoria S. Moskvina, Olexandr V. Kucher, Aleksandr I. Boiko, Anna L. Banasevych, Dmytro Durylin, Volodymyr S. Brovarets, Oleksandr O GrygorenkoAn efficient approach to the multigram synthesis of 2‐((hetera)cyclo)alkylchromanols and their spirocyclic analogs based on enzymatic resolution is described. It is shown that enzymatic acylation could be used for the preparation of enantioenriched title compounds with primary alkyl substituents at the C‐2 position. Meanwhile, enzymatic hydrolysis of the corresponding acetates was optimal for the preparation
-
Modern Methods for Conjugated Polymers Preparation: A Concept of Transition Metal‐Free Synthesis Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-06
Tomaž Kotnik, Sebastijan Kovačič -
Ni‐SPO‐Al Catalyzed Stereoselective C–H Alkenylation of Quinazolinones with Alkynes to Prepare trans‐Isomers Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-04
Yaqi Zhang, Qiang Ni, Rihui Cao, Long Jiang, Liqin QiuA stereoselective Ni−Al bimetal‐catalyzed C−H alkenylation of quinazolinones with alkynes has been successfully developed. Good selectivity of Z‐type quinazolinone products was obtained using readily available substrates, which exhibits a trans‐configuration opposite to the conventional alkynylation reactions and improves the diversity of quinazolinone compounds. In addition, the reaction process was
-
Versatile Synthesis of Linalool‐Derived Compounds via Catalytic Epoxidation and Ring Opening Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-03
Patricia Alejandra Robles-Azocar, Leandro Duarte Almeida, Alexandre P.S. CostaThis study focuses on the selective epoxidation of linalool to produce linalool epoxide, a valuable intermediate for the synthesis of novel linalool‐derived compounds. A robust and non‐noble cobalt catalyst was employed to achieve high yields of linalool epoxide under mild reaction conditions. The catalytic system displayed remarkable efficiency and reusability, providing a platform for exploring different
-
Synthesis of Vinyl Sulfones from Substituted Alkenes via Molybdooxaziridine Catalysis Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-03
Gustavo Moura-Letts, Erin L. Doran, Jenna M. Doran, Ali A. Pinarci, Morgan E. Rossi, Rufai Madiu, Amari M. Howard, James L. Stroud, Dominic A. Rivera, Dylan A. Moskovitz, Alyssa N. Singer, Steven J. FinneranHerein we report the MoO2Dipic promoted sulfonation of alkenes using N‐Ts‐hydroxylamine as the quantitative source of Ts. The reaction works with high yields and stereoselectivities for styrenes with a wide variety of substitution patterns. A novel atom transfer radical addition mechanism involving the formation of molybdooxaziridine complex 1 as the active catalyst, difunctionalization with Ts‐NO
-
Elucidating Fluorine Steering Effects in Diels‐Alder Reactions Interfaced with Charge‐Enhanced Reactivity Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-03
Sabrina Hoford, Julius Jan, Jeffrey N. Johnston, Travis DuddingFluorinated molecules are core to contemporary drug discovery programs and critical for advancing innovation in numerous fields. In merging these important chemical themes, fluorinated Diels‐Alder cycloaddition products are a particularly attractive subset of compounds with significant utility. Herein, an in‐depth computational and experimental study of fluorine substitution effects on dienophile partners
-
Synthesis of Chiral Heterocycles Through Enantioselective Silver‐Catalyzed Transformations Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-02
Hélène PellissierThe review focusses on the synthesis of chiral heterocycles through enantioselective silver‐catalyzed transformations published since 2018. The power of chiral silver catalysts as special mild Lewis acids is applied to develop 1,3‐dipolar cycloadditions, complex domino/tandem reactions, and miscellaneous cyclizations, allowing novel chiral heterocyclic products to be achieved in high enantioselectivities
-
Diastereoselective Entry to Novel Aminoindolizidines with Fused Furan, Thiophene, and Pyrrole Ring Starting from L‐Glutamic Acid Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-01
Adam Daïch, Paula Fraňová, Peter Šafář, Ján Moncoľ, Ivana Žídeková, Štefan MarchalínA series of novel optically pure aminoindolizidines featuring fused tetrahydro‐furan, thiophene, or pyrrole ring were synthesized from the proteinogenic L‐glutamic acid as a chiral precursor and a nitrogen atom source. The synthetic sequence employed tricyclic indolizidinols as advanced building blocks, which were prepared on a gram‐scale from bioavailable reagents. Key transformations within the used
-
Quinoid Carbene Mediated C(sp2)‐Heteroatom Bond Formation Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-31
Hongying Cheng, Xiaokun Wang, Kai Tan, Xiaoyu Ren, Zhen Guo, Chengming Wang, Cong-Ying ZhouC(sp2)‐heteroatom bonds play a critical role in biologically active molecules, pharmaceuticals, and functional materials. Traditional methods for synthesizing these bonds often rely on transition metal‐catalyzed cross‐coupling reactions, such as the Buchwald‐Hartwig and Ullmann reactions, which have limitations, including the requirement for elevated temperature and basic conditions. In recent years
-
Multicomponent Modular Synthesis of Thioacetals by Using Dichloromethane as the C1 Synthon under Mild Conditions Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-31
Meng-Jun Xie, Li-Hua Wen, Xuan Li, Ming-Yan Chen, Yu-Bing Li, Hai-Dong XiaThioacetals are an important category of sulfur‐containing compounds and versatile building blocks. Therefore, there is growing demand for the development of practical and modular methods to access various thioacetals from inexpensive and readily available commodity chemicals. Herein, we describe a novel one‐pot multicomponent protocol for thioacetals synthesis, especially benzylthio thioacetals synthesis
-
Glycosyl esters as stable donors in chemical glycosylation Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-30
Someswara Sanapala, Sumit Pareek, Pavan MandadiEfficient glycosylation methods are continuously being developed to obtain homogeneously pure carbohydrates to study their biological roles. The development of effective and stereoselective glycosylations using novel anomeric leaving groups constitutes an active area of research in synthetic carbohydrate chemistry. Although various glycosyl donors have been developed over the decades, anomeric esters
-
Greening the Synthesis of 2,3‐Dihydrobenzofuran Selenides: I2/TBHP‐Promoted Selenocyclization of 2‐Allylphenols Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-30
Ricardo H. Bartz, Pedro S. Souza, Lucas E. B. Iarocz, Paola S. Hellwig, Raquel G. Jacob, Márcio S. Silva, Eder J. Lenardão, Gelson PerinIn this work we describe the synthesis of selenium‐containing dihydrobenzofurans through the selenocyclization reaction of 2‐allylphenols. The reaction procedure uses only an I2/TBHP oxidant system at room temperature, enabling an efficient synthesis of 2‐[(organoselanyl)methyl]‐2,3‐dihydrobenzofurans. The products are formed immediately after the addition of the oxidant system in a mixture of 2‐allylphenol
-
Carboxylic Acid‐Catalysed Transamidation of Boc‐Protected Diketopiperazines (Boc‐DKPs) for Peptide Synthesis Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-28
Kazumasa Kon, Hisashi YamamotoA carboxylic acid‐catalysed transamidation of Boc‐protected diketopiperazines (Boc‐DKPs) was developed in this study, which allowed access to various tripeptides featuring a D‐proline residue in good‐to‐high yields within 30 min. Subsequent coupling reactions between the Boc‐DKPs and di‐, tri‐, and tetrapeptide esters were successfully performed, furnishing the corresponding tetra‐, penta‐, and hexapeptides
-
Metal‐Free Direct Synthesis of Secondary Amides and Nitriles Using O‐(2‐Pyrimidinyl)‐N‐Boc Hydroxylamine Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-28
Ashirwad Divedi, Saumya Verma, Dinesh Chandra, Shivam Bhargav, Ved Prakash Verma, Jawahar L. JatA novel hydroxylamine‐derived aminating agent, O‐(2‐pyrimidinyl)‐N‐Boc hydroxylamine (PymONHBoc), has been designed and synthesized, from readily available 2‐chloropyrimidine. This reagent demonstrates superior shelf stability and ease of handling compared to other hydroxylamine‐derived reagents. Here, we present a metal‐free method for the direct conversion of ketones and aldehydes into sec‐amides
-
Cs2CO3‐I2 Promoted Efficient Synthesis of Flavones and Flavanones: Total Synthesis of Narengenin and Apigenin Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-28
Rohan Erande, Kailas Arjun ChavanFlavonoids are an important class of naturally existing scaffolds known for their diverse biological activities and have been immensely synthesized using stoichiometric reagent amounts. Herein, we report a reliable, robust, one‐pot, transition metal and additive‐free protocol for the synthesis of flavones and flavanones from 2‐hydroxyacetophenone and substituted aldehydes. Our developed method utilizes
-
Rhodium(III)‐Catalyzed [4+2] Annulation of N‐Hydroxyoximes with Maleate Esters/2‐Chloroacrylates: Synthesis of Isoquinoline‐3,4‐Dicarboxylates and Isoquinoline‐3‐Carboxylates Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-27
He Li, Tao Chen, Zhiwei Wang, Yuxin Li, Baoheng Wu, Ning Xu, Ye Lu, Xinxin Jin, Jiaqi Yu, Jinglin Liu, Ming Bao -
Solvent‐Directed Regioselective Cascade Reaction with Diazo Compounds Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-27
Menghua Dong, Chunan Wang, Lewan Li, Yufan Chen, Jie Zeng, Jian Lv, Jie Liao, Haifeng Wang, Shuang-Xi Gu, Fen-Er ChenA tandem system comprising cyclization reaction of diazo compound and cross‐coupling of the other one has been developed. This provides facile access to pyrazoles and there derivatives with high levels of regioselectivity in moderate to good yields. This process uniquely utilizes CF3CH2OTf both as a solvent and a catalyst under mild conditions. Mechanistic studies provide insights into the intricate
-
Construction of Dibenzo[a,c]carbazoles through Oxidative Diels‐Alder Reaction of 2‐Phenyl‐1H‐indoles and Benzynes Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-27
Xinlu Xu, Yanqiao Wang, Weijie Xu, Qi Wei, Xin Ruan, Xiaofeng Zhang, qiufeng huangWe present here a convenient synthesis of the dibenzo[a,c]carbazoles via oxidative [4+2] Diels−Alder cycloaddition of 2‐phenyl‐1H‐indoles with benzynes. The features of this protocol include the use of readily available raw materials, molecular oxygen as the oxidant, it being free of transition‐metal‐catalyst, and convenient method for the preparation of π‐extended dibenzo[a,c]carbazoles.
-
Case studies of dimensionality in chemical data Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-24
Alex Blokhuis, Robert PolliceThe ambition to relate intrinsic features of chemical data to the underlying chemical reaction networks (CRNs) is not new, but has experienced only modest success. This may partly be attributed to a lack of theoretical groundwork connecting idealized theory to actual experimental data with added complexity. In particular: i) many CRNs have species that cannot be directly observed experimentally; ii)
-
Brønsted‐Acid Catalyzed Aldehyde Insertion to Construct C‐X Bond: High Regio‐ and Chemoselectivity Synthesis of Dihydrobenzo[1,5]oxazocines and Pyrrolo[3,4‐d]tetrahydropyrimidines Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-24
Teng Liu, Yuanmin Wen, Guiyun Zeng, Junjie Li, Zeng-Hong Yao, Chi-Xian He, Chao HuangAldehydes as one of the most widely building blocks, have been frequently utilized as privileged C1 electrophile units and exhibited versatile applications to construct carbon‐heteroatom and carbon‐carbon bond. We herein described a novel Brønsted‐acid catalyzed aldehydes insertion reaction with maleimide‐based 1, n‐C, O/N‐synthons, involving a high regio‐ and chemoselectivity [6/7 + 1] or [3 + 1 +
-
Unraveling Phenanthrenoid Dimerization in Juncus acutus: A DFT‐guided Exploration of Radical‐Coupling Reaction Mechanisms Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-23
Federico Coppola, Paola Cimino, Nadia Rega, Simona Zuppolini, Giovanni Di Fabio, Armando ZarrelliJuncus acutus is a plant found near ponds and brackish marshes, producing secondary metabolites like phenanthrenoid dimers with antibacterial, antioxidant, and anti‐inflammatory activities. Despite this, little is known about the detailed mechanisms behind their dimerization reactions. In this study, we used Density Functional Theory to explore the reaction mechanisms of phenanthrene and dihydrophenanthrene
-
Front Cover: Recent Developments in the Photochemical Reactions of N‐Heterocyclic Compounds (Eur. J. Org. Chem. 48/2024) Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-23
Jayaveerapandiyan Barathkumar, Rohan Gupta, Subbiah Nagarajan -
An Electrochemical Method for the Direct Sulfonylation of N-(4-hydroxyphenyl)-sulfonamides with Sulfonyl Hydrazides Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-23
Yanan Li, Lin Li, Feiyang Li, Shuaihu Hu, Rui Zhu, Jianan Sun -
Modular Synthesis of Tetracyclic Heteroarenes via Platinum-Catalyzed Cyclization of Ethynylbiaryl Precursors Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-23
István Jablonkai, Marcell M. Bogner, Barnabás Zsignár-Nagy, József Simon, Gábor London -
Utilizing N-Hydroxylamine-Based Active Esters for the Synthesis of Oseltamivir Amide Derivatives Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-23
Barbora Zahradníková, Zuzana Mravíková, Viktória Némethová, Petra Polnišerová, Vladimír Frecer, Mária Mečiarová, Radovan Šebesta -
Concise Four‐component Synthesis of Solid‐state Fluorescent α‐Sulfenylated Enaminones Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-23
Gereon Hendrik Schmitz, Wiebke Kramer, Leonard Karl, Christian Ganter, Thomas J. J. MüllerAcid chlorides, alkynes, amines, and N‐thiosuccinimides react in a consecutive four‐component alkynylation‐addition‐sulfenylation sequence to give α‐sulfenylated enaminones in good to excellent yields. The terminal sulfenylation step is catalyzed by Yb(OTf)3 and both N‐arylthiosuccinimides and N‐alkylthio succinimides can be successfully employed. Most products are solid‐state luminescent with fluorescence
-
Recent Advances in Chalcogenation of α-Amino Acids/Peptides: Synthetic and Mechanistic Aspects Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-23
Raghunath Bag, Malobika Kar, Nagendra K. Sharma -
A Sequential Nitro-Michael Addition and Reductive Cyclization Cascade Reaction for Diastereoselective Synthesis of Multifunctionalized 3,3′-pyrrolidinyl-spirooxindoles Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-23
Chandrakant B. Nichinde, Meema Bhati, Amardipsing S. Girase, Baliram R. Patil, Suryakant S. Chaudhari, Rama Krishna Gamidi, Kavita Joshi, Anil K. Kinage -
Multigram Synthesis of 3‐Azabicyclo[3.1.1]heptane Derivatives Including Bicyclic Thalidomide Analogs Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-23
Viacheslav Lysenko, Anton Portiankin, Oleh Shyshlyk, Timur Savchenko, Kostiantyn Nazarenko, Alexander Kostyuk, Oleksandr V. Golovchenko, Volodymyr S. Brovarets, Oleksandr O GrygorenkoAn efficient approach to the multigram synthesis of 3‐azabicyclo[3.1.1]heptanes is described. The method relied on the intramolecular imide formation in the properly 1,3‐functionalized cyclobutane derivative. In turn, the latter compound was obtained via the diastereoselective Strecker reaction of readily accessible 3‐oxocyclobutanecarboxylate. The resulting synthetic intermediate – 1‐amino‐3‐azabicyclo[3
-
Mechanistic Studies on the Michael-type Addition of Amines to 2-Arylvinylidenebisphosphonates: Bisphosphonate Elimination via a Retro-Aza-Michael-type Reaction Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-23
Juan M. Sonego, Martina E. Beviglia, Carlos A. Stortz, Juan B. Rodriguez -
An Efficient Synthetic Methodology for the Preparation of Glycosyl β-diketones Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-23
Ivan A. Barri, Macarena S. Le Pors, Pedro A. Colinas -
Facile Access to Phospholene Fused Polycycles through Intramolecular Alder-Ene Reaction of Phosphole Sulfides Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-23
Dingjin Geng, Aoyang Ma, Zhenhua Dong, Jinkui Chai -
Recent Development of DNA‐based Biohybrid Systems Driven by Light Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-23
Michael Smietana, Zachary Pastorel, Juliette Zanzi, Yves Canac, Olivier BasléPhotochemistry has provided a powerful alternative to generate reactive intermediates under mild reaction conditions and photobiocatalysis is currently widely applied in organic synthesis. While enzyme‐based photocatalysis has attracted a lot of attention, light‐driven DNA‐based biohybrid systems are also increasingly being applied to a large variety of applications from molecular imaging to enantioselective
-
Samarium Diiodide/Samarium‐Mediated Deoxygenative Hydroborylation of Aldehydes Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-23
Chengwei Liu, Yilin Ma, Wei ZhouA samarium diiodide/samarium‐mediated direct deoxygenative hydroborylation of aldehydes with hydroborate ester has been reported. In this method, unactivated aldehydes and hydroborate ester have been employed as starting materials for the synthesis of primary alkyl borate esters. Broad substrate scope and excellent functional group tolerance has been demonstrated that this is a robust method for deoxygenative
-
Selective synthesis of cyclic dithiocarbonates using bis‐benzimidazolate salts as multifunctional catalysts Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-23
Stephany Larissa da Silva Ribeiro, Cecília Maria Alves de Oliveira, Thaís Vieira Pereira da Silva, Olga Soares do Rêgo Barros, Meiry Edivirges Alvarenga, Felipe Terra Martins, Jorge Luiz Sônego Milani, Rafael Pavão das ChagasCyclic dithiocarbonates of the type 1,3‐oxathiolane‐2‐thione were selectively and efficiently produced from the reaction between epoxides and CS2 using disodium bis‐benzimidazolate salts as catalysts. We have designed and synthesized three nucleophilic catalysts from the neutral forms of bis‐benzimidazole compounds (BBE‐Me, BBE‐H and BBE‐NO2), through simple procedures. All three catalysts, with aryl
-
Use of Real-Time In-Situ UV-vis Spectrophotometry as a Tool for Monitoring Electrochemically-Mediated Organic Synthesis Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-23
Chelsea M. Schroeder, Nicholas E. Leadbeater -
Reactions of Unsymmetric Chiral Dialdehydes with Lysine: Regio- and Enantioselective Macrocyclization and Fluorescent Sensing Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-23
Yifan Mao, Yichen Li, Stephanie Davis, Lin Pu -
Chiral Sulfoxide Ligands in Asymmetric Allylic Substitution Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-23
Xiao Li, Sheng-Cai Zheng, Xiao-Ming Zhao -
Electrochemical Alkoxylation of Benzylic C(sp3)−H Bonds Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-23
Naixuan Zhao, Geyao Xie, Miao Zheng, Shunzhen Chang, Zhenwei Zhang, Guoxue He, Yu Zhou -
Trimethylsilyl Polyphosphate Promoted Efficient Synthesis of 4(3H)-Quinazolinones from Methyl Anthranilate Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-23
Nadia Gruber, Emiliano E. Burin, Natalia B. Kilimciler, Mariana L. Cambiaso, Liliana R. Orelli, Jimena E. Díaz -
Recent advances in allylic fluoride synthesis Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-23
Satoru Arimitsu, Daiki TomonThe recent decades have witnessed considerable progress in the development of fluorinated‐building‐block strategies and direct‐fluorination techniques selectively affording allylic monofluorides and gem‐difluorides. For allylic monofluorides, high enantioselectivities were achieved, even for fluorinated tertiary carbons, with expanded substitution patterns on vinylic moieties enabling precise control
-
Catalytic Transfer Hydrogenation of Dimethyl 1, 4-cyclohexane Dicarboxylate into 1, 4-cyclohexanedimethanol over Cu/ZnO/Al2O3/ZrO2 Catalysts Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-23
Huiwen Meng, Qian Lei, Conger Deng, Linlin Liang, Zijian Wang, Weixin Lei, Honglin Chen -
Alkynyl Phenyl Selenides as Intermediates in the Metal‐Free Cyclisation of N‐Tosyl Homopropargyl Amides to γ‐Lactams Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-23
Andrea Temperini, Giulia Brufani, Stefano Santoro, Luigi VaccaroIn this work, we present an efficient Brønsted acid‐catalysed intramolecular hydroamination reaction of homopropargyl N‐tosyl amides to produce synthetically useful substituted γ‐lactams through the corresponding alkynyl phenyl selenide intermediates. Our focus on optimising the cyclisation protocol under flow conditions has led to a significant enhancement in efficiency, thereby reducing the time
-
Front Cover: Filling the Gap within 10‐Membered Heteroenediynes: Thiaenediyne – An Experimental and Theoretical Study (Eur. J. Org. Chem. 47/2024) Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-21
Natalia A. Danilkina, Ekaterina A. Khmelevskaya, Andrey A. Shtyrov, Mikhail N. Ryazantsev, Alexander F. Khlebnikov, Elena Yu. Tupikina, Andrey M. Rumyantsev, Alexander S. D'yachenko, Irina A. Balova -
PHOTOCAT24: The Best of the First Edition Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-19
Katy Medrano‐Uribe, Sara Cuadros, José J. Garrido‐González, Giulio Goti, Daniele Mazzarella, Luca Dell'Amico -
Front Cover: Strategy for C−H Functionalization of Cubanes: From Stoichiometric Reaction to Catalytic Methodology (Eur. J. Org. Chem. 46/2024) Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-18
Masaki Hosaka, Shota Nagasawa, Yoshiharu Iwabuchi -
Cerium-Catalyzed Ritter-Type C−H Amination of Alkylarenes Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-17
Renpeng Guan, Tianlin Wang, Elliot L. Bennett, Zhiliang Huang, Jianliang Xiao -
Synthesis and Biological Activity of 2,6-Disubstituted 7-Deazapurine Ribonucleosides Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-17
Ugnė Šinkevičiūtė, Marcela Dvořáková, Michal Tichý, Soňa Gurská, Kateřina Ječmeňová, Lenka Poštová Slavětínská, Petr Džubák, Marián Hajdúch, Michal Hocek -
Magnetite: a Green, Sustainable and Recyclable Catalyst for Direct Synthesis of Thioesters by C‐H Activation Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-17
Yanina Moglie, Joaquín Marchán-García, Mariana Alvarez, Gabriel RadivoyA green and sustainable approach to the direct synthesis of thioesters has been developed using Fe3O4 as a low‐cost, easily prepared, reusable and environmentally safe catalyst. The cross dehydrogenative coupling (CDC) of various thiols and aldehydes in water, or even in the absence of solvent, using tert‐butylhydroperoxide as oxidant, under ligand and base‐free mild conditions, afforded the corresponding
-
Divergent Synthesis of 4-Aminotriazoles Through Click Cycloaddition and Generation of Iodonium(III) Triazoles Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-16
Takumi Hayashi, Elghareeb E. Elboray, Hina Sudo, Naoko Takenaga, Hiroyuki Satake, Toshifumi Dohi -
Front Cover: Merging New and Old Concepts: Tandem Oxidative Radical‐Polar Crossover Ritter Amidation via Multicomponent Photo‐ and Electrochemical Processes (Eur. J. Org. Chem. 45/2024) Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-16
Mattia Lepori, Indrasish Dey, Cassie Pratley, Joshua P. Barham -
Iodine-Assisted Regioselective C3-H Chalcogenation of 4-Phenyl Aminocoumarin: Access to Unusual Dual Selenylation of N-Substituted Derivatives Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-13
Suhag Singh Sahay, Segufa Rahaman, Rwishanya Das, Swapan Dey -
Solvent-Induced Amplification of Chiral Superstructures of Carbazole Porphyrins in Dynamic Supramolecular Aggregates Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-13
Pooja V. Shreechippa, Dinesh N. Nadimetla, Avinash L Puyad, Ambadas B. Rode, Sheshanath V. Bhosale -
Iodine(III)-Mediated Unexpected Ring-Contraction Rearrangement and Halogenated Addition Reaction to Synthesize 3-Substituted Phthalides and Isochroman-1-One Derivatives Eur. J. Org. Chem. (IF 2.5) Pub Date : 2024-12-12
Fanjing Meng, Yihang Zhou, Wenhui Cui, Xinxin Si, Tao Liu, Yang Cao