Renewable-based furan compounds derived from 2-formyl-5-(hydroxymethyl)furan (5-HMF) were successfully employed as catalysts to synthesize cyclic organic carbonates through the reaction of carbon dioxide with epoxides. The effects of temperature, reaction time, reagent ratios, and carbon dioxide pressure were optimized before evaluating various bio-based complexing agents in combination with different

Indole-based heterocycles are commonly found in natural products and pharmaceuticals, so the synthesis of such heterocycles has become an important research area. In spite of the rapid development of this research area, the synthesis of N,N'-bisindoles remains challenging and is far less developed. Herein, we present the synthesis of N,N'-bisindoles via gold-catalyzed formal (4+1) cycloaddition of

The first total synthesis of pegaharmine I was accomplished by a three‐step strategy featuring a visible‐light‐photocatalyzed nitrone formation reaction as the key step. The structure of this natural product was confirmed by crystallographic analysis. Water‐promoted photocatalysis, achieved by incorporating water into the reaction medium, has also been established.

The employed feedstocks in chemical processes received substantial attention over the past decades, mainly due to the popularity of Werpy’s list of top‐value added chemicals from biomass reported in 2004. The conventional fossil‐based feedstocks are both depleting and can be damaging to the environment. This led to a surge to replace petroleum‐based chemicals to more renewable, bio‐based platform chemicals

A visible‐light‐driven E‐selective semihydrogenation scheme of alkyne compounds was developed for designing and synthesizing glioblastoma multiforme (GBM) inhibitors. In the present study, room‐temperature semihydrogenation reactions of various alkyne compounds were successfully achieved under the irradiation of white light. The representative reaction mechanism was decoded through theoretical calculations

The growing interest towards biopolymers application in amphiphilic conditions prompted us to explore the preparation of fluorinated cellulosic materials. Cellulose (CE) and carboxymethylcellulose (CMC) were functionalized with highly fluorinated pendants, through a nucleophilic aromatic substitution on 3‐pentadecafluoroheptyl‐5‐pentafluorophenyl‐1,2,4‐oxadiazole (FOX). leading to the corresponding

Icosahedral Carboranes have a wide range of applications in medicinal chemistry, material science, and catalysis. Although various methods have been disclosed for functionalizing carborane structures, the methods to incorporate different types of heterocycles are still lacking. This limitation is likely due to the functional group incompatibility under previously reported reaction conditions, and the

The design of some novel disubstituted 3,4‐dihydro‐2H‐1,4‐ethano‐1,5‐naphthyridine derivatives is reported under classical and flow methodologies. The series were developed from quinuclidinone, which afforded versatile platforms bearing one lactam function in position C‐2 that was then used to create C–N bond using the Chan‐Lam coupling reaction or in situ C–O bond activation via palladium‐catalyzed

An efficient strategy is demonstrated for the electrocatalyitc synthesis of 2‐aryl quinoline derivatives via an anodic dehydrogenation of 2‐aminobenzyl alcohol molecules followed by condensation with carbonyl compounds at room temperature. The current protocol requires only electricity as the green oxidant, provides the desired products in good to excellent yield and is compatible with a wide range

A Rh(III)‐catalyzed cascade C‐H activation/[3+3]spiroannulation of 3‐hydroxy‐3‐arylisoindolin‐1‐ones with iodonium ylides has been developed. The method facilitates the efficient and selective construction of spirocyclic compounds in a one‐pot manner, offering high yields and excellent conversion. The reaction proceeds via a highly regioselective process, resulting in the formation of spiro‐N,O‐ketals

We report an efficient iridium‐catalyzed one‐pot protocol for the synthesis of C2‐silylated indoles from indolines and hydrosilanes. Mechanistic investigations suggest that the transformation proceeds through a tandem dehydrogenation/C−H silylation pathway. Furthermore, an example of iridium‐catalyzed direct C2‐selective C(sp3)−H silylation of indolines is also disclosed.

A facile and efficient protocol to synthesize C2‐phosphorylated 2,3‐2H‐chromones was discovered via Brønsted acid promoted tandem addition/cyclization of enaminones with H‐phosphine oxides. The reaction exhibited a broad scope, good functional group tolerance and good yields, and featured ability of a gram‐scaled synthesis. Results of mechanistic study revealed that the reaction initially undergone

The dehydrogenative coupling of hydrosilanes with alcohols or water is a fundamental transformation in organosilicon chemistry, enabling the synthesis of alkoxysilanes, silanols, and siloxanes—key materials for coatings and adhesives. Traditionally, these reactions have relied on catalysts based on platinum‐group metals (PGMs), which are costly and scarce. The development of Earth‐abundant metal (EAM)

A series of oxazolo[5,4‐b]quinoline derivatives were synthesized via a two‐step process involving the reaction of 4‐trifluoroacetylazlactones with various substituted anilines, followed by intramolecular Friedel‐Crafts‐type cyclization and Robinson‐Gabriel oxazole formation. The systematic investigation of the photophysical properties of the synthesized compounds revealed that the position and nature

A mechanochemical methodology for the preparation of 5‐amino‐4‐cyanoxazoles through the reaction of 2‐amido‐3,3‐dichloroacrylonitriles with primary or secondary aliphatic amines (or their respective salts) in the presence of dipotassium phosphate is reported. The process is carried out by processing the mixture of starting materials in a mixer mill, with ethanol used as a liquid‐assisted grinding (LAG)

The reactions of the Rind‐based 1,2‐dihalodigermenes, (Eind)BrGe=GeBr(Eind) (1a) and (EMind)ClGe=GeCl(EMind) (1b), with two types of N‐heterocyclic carbenes (NHCs) (Im‐iPr2Me2 and Im‐Me4) resulted in the formation of the halogermylene mono‐NHC adducts, (Im‐iPr2Me2)(Eind)GeBr (2a') and (Im‐iPr2Me2)(EMind)GeCl (2b'), and the germyliumylidene cation bis‐NHC adducts, [(Im‐Me4)2(Eind)Ge]+[Br–] (3a) and

Novel bis(NHC) ruthenium complexes of the form (NHC1)(NHC2)Ru(=CRR')Cl2 (where NHC represents N‐heterocyclic carbene ligands and CRR' denotes Ph‐indenylidene or benzylidene moieties) were prepared from second‐ and third‐generation Grubbs catalysts. These complexes exhibited thermal latency in ring‐closing metathesis (RCM), cross‐metathesis (CM), and several ring‐opening metathesis polymerization (ROMP)

This study presents a visible‐light‐mediated three‐component radical reaction involving alcohols or alkanes and in situ‐formed imines. The imines, generated from aldehydes and amines, serve as key reactants, while the inexpensive and readily available sodium decatungstate (NaDT) is employed as a photocatalyst. This strategy enables the functionalization of industrially accessible alcohols or alkanes

A cascade strategy involving the reactions of enone‐tethered ketones with indoles for the synthesis of indenes is outlined in the presence of iodine as a catalyst. Halogen bonding between molecular iodine and enones activates substrates to undergo Michael addition with indoles, resulting in the formation of enolates. These enolates in situ are transformed into indenes via an intramolecular aldol condensation

Herein, we report the use of a bromine atom as a masking group for the synthesis atropisomeric diarylamines via organocatalytic N‐arylation of 7‐bromoindolines. The bromine atom acts as a bulky group to temporarily stabilize the configuration by steric hindrance. Upon unmasking, less sterically hindered diarylamines are obtained, with configurational stability potentially maintained through intramolecular

An asymmetric Michael/hemiketalization/amination process of 1,3‐diketones with 2,3‐dioxopyrrolidines catalysed by a quinine‐derived urea catalyst has been developed, which furnished a series of chiral polycyclic 1,4‐dihydropyridines in satisfactory yields and enantioselectivities (35‐94% yields for 2 steps and up to 99% ee). Moreover, the subsequent oxidative aromatization of chiral 1,4‐dihydropyridines

We report here an effective, mild and practical approach to stereoselective cross‐electrophile coupling of difluoroalkenes with alkyl halides by cost‐effective chromium catalysis. This reaction was promoted by inexpensive CrCl2 combining with bipyridine ligand and manganese as the reductant, enabling the achievement of the reductive coupling of geminal difluoroalkenes with primary, secondary and tertiary

The homocoupling of terminal alkynes is a key approach for constructing 1,3‐diynes , typically relying on copper‐based bimetallic systems. Herein, we have developed a catalytic system based on nickel chloride, using 1,10‐phenanthroline as the ligand and air as the oxidant, which successfully enables the homocoupling reactions of various terminal alkynes. This reaction is characterized by cheap and

A high regio‐ and chemoselectivity route to the synthesis of 4‐quinolone derivatives involving a CsF‐catalyzed [2 + 4] tandem annulations under continuous‐flow reactor has been developed. This practical and concise protocol between aryne precursors and β‐enamino diesters provided a range of structurally diverse 4‐quinolones (28 examples) in good to excellent yields. The characteristics of this continuous‐flow

Indazoles are high value chemical building blocks used in medicinal chemistry and materials science for their distinct structural and functional features. This study details a [3+2]‐cycloaddition reaction between various aryl‐ketodiazoesters and ortho‐(trimethylsilyl)aryl triflates under mild conditions, leading predominantly to 1‐acyl‐1H‐indazoles. N‐aryl‐1H‐indazoles and aryl benzoates were also

Here a facile and efficient [2+3] and [3+3] annulation of bisnucleophiles have been developed, affording various of methylenetetrahydrofuran spirooxindole and methylenetetrahydropyrano[2,3‐c]pyrazoles derivatves under mild reaction conditions. This method provides facile and alternative strategies for the cconstruction of functionalized oxacyclic products in moderate to good yields. In addition, the

Porous organic polymers (POPs)‐based catalysts have emerged as promising materials for the conversion of low‐concentration CO2 into valuable chemicals, leveraging their high specific surface area, designability, multifunctionality, exceptional stability, and eco‐friendliness. This comprehensive review synthesizes the latest advancements in POPs‐based catalysts application for in‐situ conversion of

An unprecedented acid promoted structural reorganization of pull‐pull alkylidenecyclobutanes into 3‐substituted γ‐butyrolactones, in moderate to high yields, via a ring closure‐ring contraction followed by intramolecular ring‐opening cyclization is described.

A transition‐metal‐free procedure for synthesizing tri‐aryl substituted α‐pyrones has been developed. It involves conjugate addition, C‒O bond formation and C‒O bond cleavage. This procedure provides an efficient protocol for the synthesis of multi substituted α‐pyrones from readily available starting materials. Notable features of this program are high atom economy and transition‐metal‐free.

An efficient method for the synthesis of xylo‐nucleoside H‐phosphinate building blocks containing both pyrimidine and purine nucleobases is reported. A DNA‐phoXyloNA‐DNA chimeric sequence containing a central 2'‐5'‐phosphonomethoxy‐linked xylo‐nucleoside uracil residue was chemically synthesized, and its structural properties were examined using advanced spectroscopic techniques and computational simulations

An organocatalytic γ,γ‐regioselective formal (1+5) cycloaddition of isoindolinone‐derived propargylic alcohols with 2‐indolylphenols was established, which afforded a series of indole‐fused chromanes with potential antitumor activity in overall good yields (up to 99%). A tandem cycloaddition process was proposed based on detailed control experiments. Moreover, biological evaluation demonstrates the

Herein, we describe a simple and convenient protocol for the Markovnikov oxidation of unactivated olefins to alcohols and ketones using readily available iron salt Fe(acac)3 as a catalyst, and phenylsilane PhSiH3 as reducing material. All reactions proceed efficiently at mild conditions with air as terminal oxidant. This transformation has been applied to a variety of substrates, and is distinguished

A novel method for the synthesis of quinoxalines from o‐phenylenediamines and sulfoxonium ylides, mediated by DBU (1,8‐Diazabicyclo[5.4.0]undec‐7‐ene), is presented. This method does not require metal catalysts or oxidants, making it economical and environmentally friendly, while exhibiting excellent functional group tolerance. Mechanistic studies suggest that DBU facilitates the reaction through nucleophilic

Multi‐functional molecules with spirocyclic acetal structures have recently emerged as attractive monomers to prepare high‐performance polymers, which may subsequently be de‐polymerized and recycled under specific physicochemical conditions. Spirocyclic acetal structures can be formed by condensation of a suitable aldehyde or ketone with a polyol so that the functionalities necessary for the polymerization

A modular synthesis of bis(phosphine) monoxide (BPMO) ligands has been realized using the Michaelis‐Arbuzov reaction of dialkylphosphinite esters. The modular synthetic method allows the chemoselective synthesis of BPMO ligands in which the substituents on the two phosphorus centers are different. This methodology also provides a route to NHC‐phosphine oxide ligand precursors.

Hydroformylation of α,β‑unsaturated esters is an atom‐economical route towards aldehydes as precursors for pharmaceuticals. In this work, regioselective hydroformylation of an α,β‑unsaturated ester to the β‑aldehyde was initially re‐evaluated using a commercial Rh catalyst sample named [HRh(PPh3)4] due to reported high selectivity for the β‐aldehyde with this type of catalyst. However, while such high

This study presents a sustainable and efficient method for synthesizing a spiroborate ester (MBO) from α‐mangostin (MN), a natural xanthonoid isolated from the pericarp of mangosteen fruit. The synthetic process, structural characterization and photophysical properties of MBO are thoroughly discussed. MBO exhibits an absorption band at 370 nm, with a shoulder around 410‐450 nm in non‐polar solvents

The core pathways of autotrophic microbial metabolism have been proposed to be fossils of self‐organized prebiotic chemistry. In recent years, numerous reactions within these pathways have been shown to occur nonenzymatically, supporting this hypothesis. However, the phosphorylation of carboxylic acids to the corresponding acyl phosphates, a recurring metabolic reaction, has notably yet to be demonstrated

A simple and straightforward method has been developed for the direct synthesis of unsymmetrical Z‐azo‐aryl compounds from p‐quinone methide (p‐QM) and arylhydrazine. This reaction strategy is executed in air under basic conditions and affords exclusively Z‐isomers in good yields with a broad substrate scope. The stereochemistry of our synthesized azo‐arenes has been confirmed by 2D‐NMR analyses.

A highly efficient multigram synthesis of fused sultams (up to 97 g in a single run) via the regio‐ and diastereoselective [3 + 2] cycloaddition reaction of α,β‐unsaturated sultams was developed. The scope and limitations of the method were studied by evaluating common 1,3‐dipolar compounds. The reactions with azomethine ylide (obtained from N‐(methoxymethyl)‐N‐(trimethylsilylmethyl)benzylamine), nitrile